* HilariousInHindsight: The episode "The Spyder Man", at one point, features the titular villain's spider-robots being crushed by a falling [[Manga/JojosBizarreAdventureStardustCrusaders Road Roller-da!]] (identical in appearance to the one in the latter anime).
* OlderThanTheyThink: The trend of [[{{Animesque}} anime-inspired Western animation]] is often thought of as having begun in the 1990s, or the 1980s at the earliest. But ''Frankenstein Jr.'' was the first American animated series to be directly inspired by contemporary anime tropes.
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