* AdaptationDisplacement: So... how many of you knew this was a series of books before it was ever a cartoon?
* AudienceAlienatingPremise: It came out at a time when {{Grossout Show}}s were on their way to becoming {{discredited|trope}}, and is fittingly obscure as a result.
* BigLippedAlligatorMoment: The first episode has the two boys explaining to a large crowd how they met Fleabag Monkeyface. One part of the flashback has them introducing the crowd to the Smugleys for ''absolutely no reason whatsoever'' (other than being a ham-handed way of introducing the characters to the audience). It wasn't even included within the flashback just for writing convenience; the scene actually cuts back to reality to have one of the boys explain to the crowd who these two people (who don't appear for the rest of the episode) are.
* BileFascination: The main reason why most people watch the show.
* MemeticMolester: Dirk. He’s essentially an anthropomorphic penis. Nuff said.
* QuirkyWork: When you see a [[FunnyAnimal disco Egyptian camel]] stop a ZombieApocalypse where the zombies are made of ''camel dung'' just by dancing, you ''have'' to question if the creators are taking acid.
* SerialNumbersFiledOff: So, two trouble-making boys, one white, one black, [[CreateYourOwnHero create their own]] {{superhero}} based on their love of ToiletHumour and [[CreateYourOwnVillain accidentally spurn a]] [[TheNapoleon short-fused]] MadScientist into becoming their ArchEnemy. [[Literature/CaptainUnderpants Somehow, that seems very familiar...]] As if to drive the point home, both boys have very similar names (Gene and George for the black kids, Harold and Gerald for the white kids). The similarities extend even further when one throws the books into the equation, with Gene and Gerald being drawn very similarly (albeit slightly older-looking) and the covers of the books featuring similar parody blurbs to those of ''Captain Underpants''.
* SoBadItsGood: The show is so ludicrous and disgusting that you have to actually see it to believe it.
* SpecialEffectFailure: Some have noticed that the red-headed girl is merely a clone of her brother with hair added. The Special Effects Failure lies in how one can actually ''see the line where the boy's hair ends'' where the girl's longer hair was added.
* {{Squick}}: [[ToiletHumor Given the show's main content...]]
* UnfortunateCharacterDesign: Dr. Dirk Spamflex, [[WesternAnimation/SamuraiJack what a freak! Guy's head looks like a talking penis.]] Not helping is that [[AccidentalInnuendo he's dressed as a chicken]] and that his name sounds similar to [[ADickInName Dick]].