* CargoShip: [[{{Squick}} This]], from the end of "Li'l Griffins":
-->'''Peter:''' I'm going to go microwave a bagel and have sex with it.
-->'''Quagmire:''' Butter's in the fridge!
* HarsherInHindsight:
** In "Lil' Griffins", Peter tells Tom and Diane to "make like Siamese twins and split...and one of you die". [[spoiler: Diane would be KilledOffForReal in "And Then There Were Fewer".]]
** Mayor West contracting lymphoma became this when the real life Creator/AdamWest died of leukemia in the June of 2017.
* HilariousInHindsight: While the rest of her family get useful superpowers, Meg only gets the ability to make her fingernails grow. If only she had received this "superpower" after [[Recap/FamilyGuyS11E11TheGiggityWife Fingernails4Cash.com became a thing]], she could have made a fortune.