* CompleteMonster:
** ''ComicBook/FallOfCthulhu'': [[TheChessmaster Nyarlathotep]] himself manipulates everything for the purpose of unleashing his master Azathoth unto the universe and [[KillAllHumans eradicating humanity]]. Nyarlathotep's HistoricalRapSheet is endless, having spent centuries perpetuating insanity, suicide, and catastrophe around him, in one case eradicating {{Atlantis}} after having [[DrivenToMadness driven the entire population into madness]], keeping the only survivor as an immortal cat he keeps by his side for the thrill of eternally tormenting him. In the present day, Nyarlathotep, under the guise of "Mr. Arkham," ruins the life of Cy Morgan before having him tortured and leaving his insane form as almost an afterthought. Bringing his followers into the world one-by-one through the deaths of others, Nyarlathotep in particular drives a [[WouldHurtAChild 7-year-old child]] so insane he kills his own parents, before killing him and using his hollow corpse as a vessel for his followers. Among his other cruel actions, Nyarlathotep hypnotizes the residents of a bar into burning themselves alive; hideously tortures the heroes; and has the brain of his human follower Connor extracted and set up to look in a mirror until he's driven insane, [[AndIMustScream unable to move or die]]. Nyarlathotep seeks nothing less than to drive all humanity insane [[ForTheEvulz for kicks]] before eradicating them.
** ''The Calling: Cthulhu Chronicles'': [[OmnicidalManiac Abisso Nero]] is a [[CorruptCorporateExecutive reclusive fashion mogul]] secretly practicing as the leader of an [[ApocalypseCult omnicidal, Cthulhian cult]]. Nero and his cult abduct psychic children bearing the mark of Cthulhu, murder their parents, and indoctrinate them to become conduits to end the entire universe through eldritch, psychic energy. Nero's previous attempt at this ritual resulted in nearly 2,000 fatalities, the children included. Nero has no compunction [[BadBoss having his own followers killed]] and even [[AbusiveParents tried to indoctrinate his own son Stefano]] to use him for the cult's purpose.
** ''YMMV/{{Hexed}}'' has Yves. See that page for more details.
* EnsembleDarkhorse: The Harlot, a green-skinned mutant of a woman in a doll's outfit, is probably the closest we'll ever get to FanDisservice in a Lovecraft story. [[spoiler:That she out-manuevered Nyarlathotep and manipulated the entire cast might have something to do with it, too.]]
* MagnificentBastard: The Harlot, the HumanoidAbomination that serves as the Keeper of Secrets, was once a mortal human named Fastrada who took on the role of Keeper to save the life of her daughter. The Harlot knows nearly every secret in reality, and demands prices for those who barter with her for her knowledge, anything from precious memories to their very sanity. The Harlot schemes against the wicked Nyarlathotep and gives Cy Morgan the knowledge of the one thing that can vanish Nyarlathotep--the invocation of his true name--and waits until the crucial moment of Nyaralthotep's victory to reveal this, utterly derailing the Crawling Chaos' sprawling plan and sending him screaming back to Azathoth. The Harlot trains master thief Lucifer to become her successor, and even when the position of Keeper of Secrets is briefly usurped from her, the Harlot manages to see the thief slain by Lucifer and passes away as Fastrada, at absolute peace with herself.