* DiagnosedByTheAudience: At first Kyle is portrayed as having some mental disorder, then he's toned down to being ''just'' socially awkward as part of his inner conflict, and that's resolved by the end of the series.
* HarsherInHindsight:
** Ephram's comment about Nina's surrogacy that he "doesn't understand how anyone could just give up a baby" becomes so much harsher three years later.
** When Irv has a heart attack scare in season 1, Edna is terrified and spends the next few days overprotecting him until they fight about it. Later, when they make up, she tells him she watched her first husband die and couldn't stand watching it happen a second time. [[spoiler:Near the end of the final season, Irv dies and leaves Edna unable to deal with her grief.]]
** Dr. Andrew Brown's wife dying in a car crash becomes much harsher when in June 2023 his actor, Trent Williams, died in a motorcycle accident after being cut-off by a car.
* HilariousInHindsight: Apparently [[Film/GuardiansOfTheGalaxy2014 Star Lord]] and [[Film/CaptainAmericaTheWinterSoldier Sharon Carter]] are brother and sister.
* RetroactiveRecognition:
** Gregory Smith and Chris Pratt both became better known thanks to ''Series/RookieBlue'' and ''Series/ParksAndRecreation'', respectively.
** Similarly, Emily [=VanCamp=] went on to further prominence playing the lead on the TV show ''Series/{{Revenge}}''.
** Both Pratt and [=VanCamp=] joined the Franchise/MarvelCinematicUniverse in the same year, Pratt as Peter Quill in ''Film/GuardiansOfTheGalaxy2014'' and [=VanCamp=] as Agent Sharon Carter in ''Film/CaptainAmericaTheWinterSoldier''; both films were released in 2014.
* UnintentionallyUnsympathetic: Rose and Harold (and to a lesser extent Bright) fall into this big time in season 2 with their appalling treatment of Amy, first the latter attack her boyfriend Tommy during dinner (instead of expressing his concern privately which Amy later points out he should've done) and then blatantly accuses her of "FAKING HER DEPRESSION" (which in real life can drive someone who is depressed into attempting suicide) and threatens to imprison her in her own home, while Rose at first seems to be reasonable, after she finds out Amy didn't really run away (she was at Edna's) she then suddenly gets even worse than Harold by refusing to accept Amy's apology and accusing Amy of "controlling" the family (which feels more like projection on her part and comes off as downright laughable considering she's ignoring the root cause of Amy's problem) and both accuse Amy of being an "embarrassment"(Which feels more like the two of them being more concerned over their careers then about their own daughter) and also backs up Harold on the whole "home imprisonment" thing, they even act disrespectful when their priest tries to mediate things between them. It's ironic how they accuse Amy of being "immature" when they are in fact the ones doing so by just wanting her to "get over" her depression and essentially be an obedient slave to them, and then afterwards it becomes downright laughable when Rose is talking about how "shocked" she was that it didn't work, oh gee it's sooooo shocking that Amy didn't want to go back to a place where she'd become a prisoner in her own home. The show wants us to feel sorry for them, but many viewers saw their treatment of Amy as unforgivable and felt like it was impossible to see them as likable characters again after that.
* {{Wangst}}: Sometimes the teenagers could be a little over the top in their woes...
** The adults could be this as well, Harold and Rose especially after Amy runs away from home (due to the former's terrible treatment of her including "accusing her of FAKING her depression" and threatening to imprison her in her own home essentially) Rose whining and accusing Amy of "controlling" the family comes off as projection and Rose being surprised that Amy wasn't willing to come home and be imprisoned (and Amy was willing to give up her phone and car as well) comes off as downright laughable.