* FunnyAneurysmMoment: ...
** TooSoon: A brain hemorrhage, which could be termed as a FAM.
** The episode "Little Mother", where Kimberly's childhood friend learns she's pregnant involves a misunderstanding where the boys mistake Kimberly herself for pregnant. Several seasons later, Dana Plato was fired when the writers refused to incorporate her own pregnancy into the show.
* HarsherInHindsight: "The Bicycle Man" is even tougher to watch once you've learned that Todd Bridges was preyed upon by a pedophile publicist in RealLife when he was 11.
** The live studio audience laughing at the titular Bicycle Man's advances before it was outright revealed he was a pedophile. Not helped since some of the dialogue seems tailor-made to seem uncomfortable in hindsight.
-->'''Mr. Horton''': What's the old saying? You scratch my back, I'll scratch yours?
-->'''Arnold''': You keep coming up with these presents and [[AccidentalInnuendo you can scratch me all over!]]
* HilariousInHindsight: In a lot of episodes to get Arnold's attention they yell ''WesternAnimation/HeyArnold''.
** This isn't the last time Pearl the housekeeper's actress is on a show with a [[WesternAnimation/SpongebobSquarepants character named Pearl.]] She doesn't play the character in the latter show though.
* MemeticMutation: "Whatchoo talkin' 'bout, Willis?"
* NeverLiveItDown: "The Bicycle Man".
* ValuesDissonance: The whole premise of a couple inner-city black kids being "saved" by a kindly, paternalistic, rich old white guy may well provide this for some viewers.
** Certain episode plots or events within the plot may be this for some viewers. "The Spanking" from Season 1 is a biggie, considering today's attitudes regarding corporal punishment. A lighter example occurs late in the show, when Maggie scolds Sam for wetting his bed. The family doctor later explains this was the wrong way to handle the situation, but it's still disconcerting, especially since Phillip reassures Maggie that she technically did nothing wrong. A plethora of similar examples exist.
* ValuesResonance: On the opposite token, the scene where everyone discusses the Aesop of ''The Bicycle Man'' has Willis express surprise that Mr. Horton is "[[AllGaysArePedophiles gay]]." The detective who busted Mr. Horton bluntly but politely points out there's a world of difference between gays and pedophiles. In a decade that wasn't particularly gay-friendly, [[SomeAnvilsNeedToBeDropped that was a very important lesson to learn]], even if it wasn't the focus of the episode.