* BigLippedAlligatorMoment: At the end of "Hot Enough for You?" Valerie walks out of Childrens' and launches into a dance routine parodying the opening to ''Film/DoTheRightThing'' with the rest of the major cast members to a song titled "I Killed Cancer". Not to mention the ActorAllusion moment for Kurtwood Smith who plays both the evil big pharma man trying to stop the cancer cure as well as Red Foreman on ''Series/That70sShow'' which often does this sort of dance moments.
* DudeNotFunny: The mere premise of a ''[[BlackComedy comedy]]'' show set inside a children's hospital has turned off a great deal of potential viewers.
* EarWorm: "I Killed Cancer"
* SugarWiki/FunnyMoments:
** A man has been comatose for many decades and a psychic little girl goes into his mind using telepathy and talks to him. But having been in a coma for so long, he's not up to speed on current events.
-->'''Comatose Man:''' [[BlackComedy Hey, did they ever finish building that World Trade Center in New York?]]\\
''[seconds later]''\\
'''Comatose Man:''' One more random thing; [[CrossesTheLineTwice how did that Challenger flight go?]]
** "[[https://www.youtube.com/watch?v=Kc2p7qulEaw Are you stupid for a living?!]]"
* TooCoolToLive: Dr. Brock Stryker, an impossibly awesome doctor introduced for a few moments specifically to be killed.