* CrowningMomentOfAwesome: Charles, Grandpa Powell, and the children unite to protect Mrs. Powell against a lecherous sailor.
* EarWorm: The theme song, so very much.
* RetroactiveRecognition:
** Charles is Scott Baio, also known as [=ChaChi=] from ''Series/HappyDays''. Charles may be in charge, but The Fonz is in charge of Charles.
** Buddy is also Series/{{Bibleman}} and [[Series/EightIsEnough Tommy Bradford]].
** Creator/MegRyan played a rival that was critical of Charles' child-rearing techniques (while being interviewed for a position in Charles' nanny agency) in "Charles 'R' Us".
** The guy who Stan and Jill oh, so mistakenly thought was Lila's date in "The Wrong Guy" was [[Series/{{Friends}} Chandler Bing]].
** [[SavedByTheBell Zack Morris]] was a classmate of Sarah's in "Runaround Charles".
** PaulWalker and [[Series/{{Sliders}} Jerry O'Connell]] have played the respective love interests of Jamie and Sarah. [[note]]In the case of Walker, clips of his appearance in the episode "Dead Puck Society" were included in profiles of his career following his death in a 2013 car accident.[[/note]]
** Buddy's sister Bunny in "The Buddy System" was [[Series/TheFactsOfLife Natalie]].
** Melanie (Jamie, Sarah and Adam's youngest cousin in the episode "Fair Exchange") later became [[Series/TheTorkelsons Dorothy Jane Torkelson]].
** [[Series/HappyDays Ralph Malph]] won the lottery instead of Walter (thanks to Charles) in "It's a Blunderfull Life".
** [[Series/LeaveItToBeaver Wally Cleaver]] played Adam's music teacher who crashed their house party (and whom Sarah took in, mistakenly believing he was a homeless man, whom he looked a lot like) in "Summer Together, Fall Apart".
** [[Series/SavedByTheBell Kelly Kapowski]] was Charles' girlfriend, who manipulated Buddy into thinking that Charles didn't want to be his friend, in "There's a Girl in My Ficus".
** Brian Levant (best known as co-creator and producer of ''Series/MySecretIdentity'') directed two episodes.
** Bonnie Franklin (best known for playing Ann Romano on ''Series/OneDayAtATime'') directed an episode.
** Dwayne Hickman (best known for playing the title character in ''Series/TheManyLovesOfDobieGillis'') also directed an episode.
** Lee Aronsohn (best known for co-creating ''Series/TwoAndAHalfMen'') wrote 13 episodes, a handful of which were with former writing partner Marc Sheffler.
** Creator/ChuckLorre wrote two episodes.
** Jim Vallely (best known as co-creator and co-executive producer of ''Series/RunningWilde'' and ''Series/BrotherlyLove'') also wrote two episodes.
** Al Jean and Mike Reiss (both of whom are best known as creators and executive producers of ''Series/TeenAngel'' and ''WesternAnimation/TheCritic'' and writers for ''WesternAnimation/TheSimpsons'') wrote an episode.
** Pamela Eells O'Connell (best known as creator and executive producer of ''Series/{{Jessie}}'' and ''[[Series/TheSuiteLifeOfZackAndCody The Suite Life on Deck]]'') also wrote an episode.