* AssPull: The 13th episode, "Love Stinks!", revolves around Blossom suddenly having a boyfriend, Ricky, who comes home from college and breaks up with her because he met someone else. This is treated as a big deal, however, for the entirety of the first season, Blossom is shown dating several boys without one mention of Ricky. Blossom is also depicted as being completely inexperienced with boys and suddenly she has a much older boyfriend that we've never seen before. It's also hard to believe that Nick, who has been established as being overprotective of Blossom, would ever let someone as old as Ricky get near Blossom.
* HarsherInHindsight: Season 5's "The Date" has Creator/JamesMarsden as the man who assaults Blossom. This becomes harsher in hindsight when you realize that eight years later, Marsden was one of the supporters of convicted child molester Brian Peck.
* HilariousInHindsight:
** Just the mere fact that the titular protagonist's name is "[[WesternAnimation/ThePowerpuffGirls Blossom]]".
** After the kids are being worn down by playing endless board games with Nick, Joey states he would rather shave his hair than keep going. In the 2000's, his actor Joey Lawrence rocked a cueball.
** Creator/TheRussoBrothers are named Anthony and Joe.
** [[https://www.youtube.com/watch?v=l7k2aAL8gZc In one episode,]] a love interest for Blossom was played by Johnny Galecki a.k.a. [[Series/TheBigBangTheory Leonard Hofstadter.]]
** [[https://www.youtube.com/watch?v=eX_sq0T7ybc In another one,]] a friend of Joey's was played by David [=DeLuise=], who would later play the father to [[Series/WizardsOfWaverlyPlace another Russo family.]]
** The B-plot of the Season 5 episode "Who's Not on First" (in which Joey goes up against Blossom and UsefulNotes/AlbertEinstein on ''Series/{{Jeopardy}}'') could count with Mayim Bialik becoming part of the rotating series of guest hosts that have hosted the show following the death of Creator/AlexTrebek; with it being subsequently announced that while executive producer Mike Richards would be the new host[[note]]as it turned out, Richards was soon ousted due to a series of controversies[[/note]]; Bialik would get to host primetime specials and any Jeopardy spinoffs[[note]]Ken Jennings, who was the first guest host of broadcasts after the final week Alex Trebek taped before his death aired, resumed his position as the interim regular series host[[/note]].
* RetroactiveRecognition:
** Creator/MayimBialik, a.k.a. [[Series/TheBigBangTheory Amy Farrah Fowler]], is Blossom.
** Creator/JoeyLawrence (Joey) went on to play Joe Roman on ''Series/BrotherlyLove'' and Joe Longo on ''Series/MelissaAndJoey''.
** Creator/JennaVonOy (Six) played Stevie Van Lowe on ''Series/TheParkers''.
** David Lascher (Vinnie) played Josh on ''Series/SabrinaTheTeenageWitch'', and prior to his role as Vinnie had previously been part of the Creator/{{Nickelodeon}} series ''Series/HeyDude''.
** In addition to his work on ''Blossom'', creator and executive producer Don Reo was co-creator and executive producer of ''Series/MyWifeAndKids'' and ''Series/TheRanch''.
** Brenda Hampton wrote 11 episodes. Hampton is best known as creator and executive producer of ''Series/SeventhHeaven'', ''Series/SafeHarbor'', and ''Series/TheSecretLifeOfTheAmericanTeenager'' and as co-creator and executive producer of ''Series/FatActress''.
** Jonathan Schmock wrote nine episodes. Schmock is best known for developing ''Series/SabrinaTheTeenageWitch''.
** Jonathan Prince wrote six episodes and directed an episode. Prince is best known as creator, co-developer, and executive producer of ''Series/AmericanDreams''.
** Josh Goldstein also wrote six episodes. Goldstein also co-developed ''Series/AmericanDreams''.
* ValuesResonance: "38 Special" became more relavent in the wake of Columbine and other mass shootings.