* BrokenBase: The 2006 series was rather divisive. On one hand, most of the original actors returned to reprise their roles and it was a straight-up SequelSeries rather than a ContinuityReboot. On the other hand, Limburger and his minions were DemotedToExtra with the Catatonians and Ronaldo Rump replacing them as the main villains.
* EarWorm: The theme song of first three seasons.
* EnsembleDarkhorse: Modo. There's an awful lot of comments that praise him.
* GeniusBonus: Tetra-Hydrocarbons from the 06 series. Otherwise known as CH[[subscript:4]]. ''Methane.''
* HoYay: Episode 49, where Modo catches Vinnie and the latter makes a comment that makes us all wonder.. And then Modo drops him in the snow.
* LGBTFanbase: Muscles, ''barely'' any shirts, heroes on motorcycles.. yeah, sounds 'bout right!
* {{Narm}}: At one point, Vinnie claims that his lips are a national treasure. It's weird because [[YouFailBiologyForever mice don't have lips.]]
** Technically, they do, but not the same we have.
** On that note, mice aren't supposed to detest cheese and have thumbs either.
*** [[ShownTheirWork Actually the cheese thing is perfectly accurate]]. Mice became associated with it because in olden times cheese was one of the few foods in the house that probably wasn't spoiled, which mice could smell.
* NauseaFuel: Plutarkians eat worms. [[{{Squick}} Yuck!]]
* TearJerker:
** In ''Chill Zone'', a little girl tells how her orphanage was destroyed - [[ManlyTears which makes Modo shed tears]].
** Harley's HeroicSacrifice in the 2006 series finale "Turf Wars".
* TheyChangedItNowItSucks: The opinion of about half the fanbase when they saw the {{revival}} series.