* [[spoiler:''PennyArcade'']] Two vitriolic friends deal with a completely insane world of videogame references and possible drug use.
* [[spoiler:''Powerup Comics'']]: The adventures of two epic, cool gamers.
* [[spoiler: ''Webcomic/{{Shortpacked}}'']]: Mentally ill war veteran's lesbian attraction leads her into the machinations of a man bent on world domination and marks the beginning of her ascent into the government of her country as she takes advice from its deposed former leader. The strip's [[AffectionateParody constant commentary on present American society]] is matched only by its [[EveryoneIsBi exploration of nontraditional sexuality]].
* [[spoiler: {{Sonichu}}]]: A young man embarks on an epic quest to find his soulmate with the help of his faithful animal companions. Along the way, our hero faces unlikely enemies, and makes [[LoadsAndLoadsOfCharacters many new friends]]. Join our hero as he topples a corrupt organization, uncovers an ancient prophecy, and attempts to defend his honor and clear his good name from those who would seek to defile it.
** or: A man sets out on a quest to find love and teach the world about Autism with the help of his electric hedgehog friends. The story is as interesting as the creator's real life.
* [[spoiler:TheEasyBreather]]: A young woman takes up the mantle of a hero determined to demonstrate positive health habits. This story will make you think long and hard about the harmful effects that certain substances can have on your body in an interesting new take on a lesson that resonates with everyone.
* [[spoiler:Shredded Moose]] A [[PornWithoutPlot simple]], well drawn, [[FetishRetardant sexy]] webcomic about [[ViewersAreMorons enjoying one's youth, having fun, and celebrating laughter]]. All the while, said comic takes a [[BlackComedy satirical look at society's ideals]].
* [[spoiler:''[[Horrible/{{Webcomics}} Single Asian Female]]'']] A young minority struggles to find her place in the Western world while still retaining her cultural identity. It manages to show a perspective not often seen while also not shying away from tough issues like racism.
* [[spoiler: ''Webcomic/{{Jack|DavidHopkins}}'']] An interesting look at morality and the struggles of life and death, from a author extremely knowledgeable when it comes to mythology. Strong Christian themes. Involves cute cartoon animals!
* [[spoiler: ''Webcomic/AxeCop'']] [[ImprobableWeaponUser With an array of unconventional weaponry]] and his equally unlikely sidekicks, a WideEyedIdealist policeman takes on the task of wiping the planet clean of all crime.
* [[spoiler:''Webcomic/EightBitTheater'']]: Based on [[VideoGame/FinalFantasyI one of the most beloved video game franchises of all time]], a diverse and colorful group of [[DesignatedHero adventurers]] embark on an exciting quest to defeat a mysterious evil force. Along the way, they must face a power-hungry dictator, an [[AWizardDidIt ancient wizard]], many [[QuirkyMinibossSquad rival factions]], and their own inner demons. Well-known for its [[{{Anticlimax}} unpredictable plot twists!]]
* [[spoiler:''ProblemSleuth'']]: A surrealist masterwork of [[WritingByTheSeatOfYourPants improvisational writing]], the sprawling story, set in an [[AnachronismStew abstraction of the prohibition era]] and drawn in a [[StickFigureComic stark black-and-white style]] reminiscent of the work's FilmNoir [[AffectionateParody ro]][[GenreShift ots]], follows three devious hardboiled detectives, who, despite being enemies, are willing to team up and use [[CrazyAwesome all their wits and imagination]] to defeat a bootlegger, while simultaneously becoming more and more dependent on drink to sustain their dream world. Spawned a massively successful SpiritualSequel.
* [[spoiler:''PennyAndAggie'']]: InAWorld full of [[ManipulativeBastard manipulators]], [[TheConspiracy conspirators]] and homicidal [[TheSociopath sociopaths]], can a [[LovableAlphaBitch good-hearted socialite]] and an [[TheSnarkKnight aloof, sharp-tongued loner]] [[IMissMom haunted by past trauma]] [[StrangeBedfellows end their long-festering enmity]] for the greater good of society, and find [[FireForgedFriends friendship]], even [[GirlsLove love]]?
* [[spoiler:''Webcomic/{{Homestuck}}'']]: Surreal, [[Music/{{Homestuck}} operatic]] tale about four young children from broken families around the world, destined to complete the cycle of time not just for themselves in the face of the coming apocalypse, but their [[{{Troll}} predecessors]] from another, long-dead world, and finally, for the [[EldritchAbomination Gods]] themselves.
** [[spoiler:''Webcomic/SweetBroAndHellaJeff'']]: A [[StylisticSuck uniquely stylish]], postmodern exploration of [[ShowWithinAShow recursive fiction]], the nature of [[HeterosexualLifePartners male friendships]] in the 21st century, and the hidden dangers of living in a [[StaircaseTumble multiple-story home]].
* [[spoiler:''Danny and Spot'']]: Two [[TheWarOnStraw well-rounded intellectuals]] with opposing views struggle to live the rest of their lives with each other. As time goes on, the two try to reconcile with each other and make the best of their existence.
* [[spoiler:''Webcomic/SquareRootOfMinusGarfield'']]: Everyone's favorite {{fat|Cat}}, [[CatsAreSnarkers sarcastic]], {{lazy|Bum}} [[ComicStrip/{{Garfield}} cat]] in [[DadaComics wacky adventures]], both new and reimagined!