* Before she [[PowerOfLove mellowed out a bit,]] Galatea fit this trope in ''Webcomic/TheInexplicableAdventuresOfBob.'' She explains her position [[http://bobadventures.comicgenesis.com/d/20080722.html thusly.]]
* Back in 2000, the webcomic ''Webcomic/{{Fluble}}'' actually had a [[http://techhouse.brown.edu/cgi-bin/fluble/vault.pl?date=20000208 storyline]] about a space monstrosity named [[ExactlyWhatItSaysOnTheTin Woobie]], who wanted to destroy the world because he felt unloved.
* ''Webcomic/DarthsAndDroids'' seems to be casting Jengo Fett in this role.
* Yonatan from ''Webcomic/FakeNewsRumble''. The only reason he's helping [[BigBad the Dark One]] with the destruction of worlds is because of his [[ChildhoodFriendRomance unrequited crush on his childhood friend]], who sought power.
* Sandra Eastlake from ''Webcomic/ZebraGirl''. After trying for two years to come to terms with accidentally being transformed (through no fault of her own) into an obviously non-human demon who cannot eat or even taste food properly, type properly (her fingers are razor-sharp, foot-long claws), sound normal (her voice sounds like [[http://www.youtube.com/watch?v=LJCYr7Skf_g the modulated noise of a cat being strangled]]), interact within normal society, or even hold a normal job, surviving multiple attempts on her and her friends' lives, being rendered incapable of intimate contact due to her bodily fluids being ''acid'', and becoming her town's very own urban monster legend, she is finally pushed over the edge by a wizard who goes out of his way to ''provoke her into becoming completely evil so that he can successfully poison her with an evil-killing toxin''. When even that fails, he simply drags her to Hell while the whole town stands by and does nothing, because he happened to look more human than she does. She finally snaps when, [[spoiler:''after they both arrive in hell'', he transforms into a demon and threatens to spend the rest of eternity torturing her]]. By that point, she has nothing left to lose.
** And as icing on the cake, consider that the only reason said wizard even knew about her in the first place is because ''she contacted '''him''' to ask for help''.
* ''Webcomic/SluggyFreelance'''s Oasis. All she wants is for her one true love to return her love, and until he does, she'll slaughter everything in her path. She ''knows'' that she was essentially brainwashed by Steve Hereti into loving Torg, but can't help it anyway. This, coupled with her not knowing exactly what she is, is slowly driving her insane(er).
* Kimiko of ''Webcomic/DresdenCodak'', [[http://www.dresdencodak.com/cartoons/dc_045.html as shown in the Hob arc]].
* Trace Legacy from ''Webcomic/TwoKinds''. A few weeks after he settles down with his new wife, a Keidran thief shoots her with a poison arrow. In his grief, he throws himself into BlackMagic research to try and resurrect her. The spell backfires, nearly killing him and destroying his sanity. He then sacks a Keidran village and takes over the Order, [[BalefulPolymorph polymorphing]] his old boss into a Keidran so he can kill her without a fuss. The Goddess of Neutrality has to wipe his brain to keep him from committing genocide.
* Tavor from ''Webcomic/LookingForGroup''. After losing his family and kingdom to invaders, he decides to take his pain out on the rest of the world by trying to erase the city representing its last hope from existence.
* Redcloak from ''Webcomic/TheOrderOfTheStick'', once you've read his backstory in ''StartOfDarkness''. [[spoiler:Entire family and village, except his brother, massacred by the supposedly LawfulGood Sapphire Guard. Teamed up with Xykon, who took over Redcloak's own team and demoted him to number 2 after Redcloak himself turned him into a Lich. Forced to kill his brother by Xykon as a twisted loyalty test]]. Recently lost an eye to one of the Sapphire Guard and was forbidden by Xykon (again) from healing it. He remains in service to a potentially world-destroying evil plan which is the only part of his old life that remains.
** [[spoiler:Darth V]] also qualifies, having snapped after being unable to [[spoiler:trance for months]] due to severe guilt, then having [[spoiler:his/her family threatened with a horrible death]]. The fallout of [[spoiler:his/her [[DisproportionateRetribution casting of]] [[MoralEventHorizon "Familicide"]] on the dragon making these threats, killing everyone even remotely related to her,]] has indeed pushed this a lot closer to a literal "Destroyer of Worlds" example -- [[spoiler:one of [[SealedEvilInACan the Gates sealing away]] [[EldritchAbomination the Snarl]] was defended by a man with dragon blood, and his family]].
* ''Webcomic/BobAndGeorge'': [[http://www.bobandgeorge.com/archives/020417c pitying Spark Man was not wise]].
* Eridan Ampora from ''Webcomic/{{Homestuck}}''. The first thing he does when he's introduced? [[spoiler:Shoot a laser through a whale. Second? Have all of his romantic advances rejected [[IJustWantToBeLoved when desperately pining for companionship]]. The last thing he does while alive? Kill his queen, kill his friend, knock out his rival, and ''doom his species to extinction''.]]
** The Handmaid, a servant of Lord English, who is, with the help of Doc Scratch, responsible for [[spoiler:turning Alternia into a CrapsackWorld and the creation of their FantasticCasteSystem.]] She's also a slave in all but name, has been [[AbusiveParents abused since birth]], wants desperately to die but can't [[WhoWantsToLiveForever due to being cursed with immortality]], and the [[HopeSpot one time she succeeded in escaping her fate]] ended with her running right into the time-traveling, universe-destroying demon himself.
*** It's not hard to feel awful for The Handmaid's pre-scratch incarnation, [[spoiler:Damara Megido, who started as a sweet, meek young girl and snapped after being bullied incessantly over a bad breakup, which itself was sparked by her boyfriend cheating on her.]] Not that it makes her actions excusable, but it's still heartbreaking.
** How about [[spoiler:Gamzee?]] He's very friendly and silly throughout Part 1 of Act 5, and only goes AxCrazy upon realizing [[spoiler:that the Juggalo religion he followed was really a musical project by a [[Music/InsaneClownPosse couple of Earthlings,]] and thus stops eating the sopor slime which kept him sane.]] It may sound ridiculous on the surface, but when you compare it to human examples of the FaithHeelTurn, you can't help but feel sorry for the poor guy.
** It's also possible to feel pretty bad for the Condesce, who spent most of her apocalyptic reign over Earth attempting to recreate the Troll society she'd essentially been banished from, desperately trying to reconnect with her own kind, only to have her every attempt fail miserably until she was left to rule over a devastated planet. You'd feel very sorry for her if she hadn't taken down humanity in the process.
* The golem girls in ''Webcomic/WapsiSquare'' played this role once. They were tortured until their wills were completely broken, then they were turned into a weapon. They ended up rampaging and destroying most of the world. Since then, civilizations have been rebuilt, and they have had their free will returned.
* [[http://hiddendepths.smackjeeves.com/comics/1407376/051-dugtrio/ Dugtrio]] in ''151 Hidden Depths'' ends up destroying cities after being refused to join the Pokemon Police Force.
* [[Theatre/ThePhantomOfTheOpera Erik]] during the Rooftop arc in ''Webcomic/GirlsNextDoor''. That cafe scene with Sarah establishes TheWoobie factor . . . right before he snaps and backslides into a full-on BastardBoyfriend StalkerWithACrush.
** In parent series ''Webcomic/{{Roommates}}'' Jareth actually destroyed a (thankfully just dream)world, when he got pushed too far in the ''Such Stuff...'' arc. (His mother manipulated his SuperpoweredEvilSide into killing his best friend... and no it wasn't a redeeming point that she was aiming at his LoveInterest either.)
* Shadow the Hedgehog from SonicTheComicOnline was created by the Drakons during the war, but his genetic make-up was never completed. After the war, the incomplete Shadow was left in Emerald Hill Zone, along with the Chaos Emeralds for hundreds of years. There he would remain, until he was eventually discovered by Doctor Kintobor. While Kintobor could never work out how to give Shadow a physical form and free him from the Omni Viewer-like container he was trapped in, he taught Shadow all he knows, including geography, science, history and politics leading Shadow to consider Kintobor to be his only friend. Then Sonic turned Kintobor into Robotnik, dooming Shadow's only friend, which lead to Shadow working to carry out his friend's last wish to destroy Mobius.