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* Spencer Reid. The guy was [[spoiler:kidnapped and shot up with dilaudid to make him addicted,]] for Pete's sake. As Reid's actor himself described; "I've been kidnapped three times, held hostage twice, I've watched my best friend kill a man, I've seen a kid commit suicide in front of me, I've been shot and even set on fire," ...and that was only after the first 3 seasons. He's since been [[spoiler: exposed to anthrax, shot (again), made it through a heroin addiction, been reunited with his absentee daddy after a decade, struggled with his schizophrenic mother, revealed his incredibly depressing high school experiences, been plagued by nightmares, not to mention threatened and generally targeted by Unsubs a couple more times]]. And in Season 8, [[spoiler:he finally seems to find a girl, only for her to be shot IN FRONT OF HIM in a murder-suicide by her stalker.]]
* Aaron Hotchner. Gideon left, Haley left, he got blowed up pretty good and watched Kate Joyner bleed to death while they were stuck in front of Federal Plaza. And THEN he was [[spoiler: stabbed nine times by The Evil Stabbity/Scrawny Bastard, Foyet, whose evil machinations require that Jack and Haley be put into protective custody, and Hotch not know where they are. He explicitly has PTSD now.]] He's bound to have the most EPIC of epic breakdowns. It's only a matter of ''when'' he [[BreakTheCutie breaks]]. Since that writing, he's lost his leadership position, he's got higher-ups doing everything they can to destroy his career, and [[spoiler: Haley is now dead, leaving him a single father.]] What else are they going to do to this poor guy?
* Jason Gideon. By the end of his character run, he's been made to feel personally responsible for the deaths of ''how'' many people? One of whom is [[spoiler: his girlfriend, who's sliced up by a psychopath ''whose freedom he was forced to help negotiate himself''. And that's just people we've seen or heard about in the series]].
* If it's possible for a single-episode character to be a Woobie, then Johnny [=McHale=] from "True Night" probably is one. [[spoiler: His pregnant girlfriend, to whom he'd just proposed, was raped and killed by a brutal gang who ''[[ForcedToWatch made him watch]]'', then slit his throat and left him for dead. Then at the the end of the episode, he discovers that the experience caused him to have a psychotic break, and he's been running around killing the gang members over the past few days without realizing what he was doing. He ends the episode sitting on the floor of an insane asylum, surrounded by drawings of his girlfriend and dialing his her number over and over just so he can hear her voicemail, because that's all he has left of her.]]
* Some of the would-be victims. Rebecca from "...A Thousand Words" is kidnapped by an unsub who commits suicide, leaving her in the hands of his pregnant wife. When the wife goes into labor, she throws the key Rebecca needs to escape out of her reach. Rebecca helps her give birth to a son, only for the wife to tell her to keep the baby away from her. Then she dies, leaving Rebecca with the newborn. As you might guess, by the time the team finds her, she's understandably freaking out.
* Or how about the father and daughter in "The Fight" who were abducted by the unsub, who forces the father to fight homeless men (in one case, to the death) or he'll kill them both? Made all the more heartwrenching by the fact that the father regrets not being the best father. Finally, the daughter agrees to leave with the unsub, if only so he'll stop forcing her father into any more fights.
* The parents of the missing boy in "A Shade Of Gray". They're clearly loving parents who are distraught over their son's disappearance [[spoiler:which makes it all the more difficult when TheReveal comes out that they (along with a cop friend of theirs) are covering up the fact that their son was ''not'' abducted, he was actually killed by ''his own brother'', who doesn't feel a bit of remorse]].
* Despite committing one of the most disturbing crimes in Season 9 by far, [[spoiler: Wallace Hines is this due to his heavy MommyIssues.]]
* Eddie Lee Wilcox is seen as this [[spoiler: after his mother died from childbirth and his father committed suicide.]] Not only that, but [[spoiler: after the [[FreudianExcuse traumatic childhood]], he started to rob banks as an adult to support his family. Despite his certain outbursts, he really wanted to spend time with his daughter for one last time before commenting suicide himself due to his self-hatred]].
* [[spoiler: Joe the clown]] of season three's "Damaged".
* Rossi's former sergeant from the Vietnam War. He had seen the worst things imaginable and knew that another soldier performed a HeroicSacrifice to save him and Rossi after the latter triggered a land mine. Forty years after the war, he's living on the streets with a group of people. The worst thing regarding this character? A serial killer starts targeting his fellow homeless friends and he witnessed one of his friends be kidnapped. Thankfully for him, Rossi gets him placed in a wars veterans home, saving him from the tragic reality that real-life war veterans face.
* Nathan Harris from ''Sex, Birth, Death'' turned out not to be the [=UnSub=], but he knew there was something mentally wrong with him (he was aroused by the idea of killing women, which terrified him) and got Gideon to do an analysis of his psyche. He later revealed to Reid he was feeling suicidal, and tried to kill himself in the coda before he was set to go to a mental hospital. Reid only just managed to save him.
* Samantha Malcolm, the [=UnSub=] from ''The Uncanny Valley''. Yes, she has kidnapped six women. Yes, she has killed three of them [[spoiler:accidentally]]. Yes, she paralyzes them. Yes, she needs a really '''big''' hug. You '''''will''''' [[TearJerker cry]] during her episode.
* And they've possibly out-{{Woobie}}d them all with Lara from "Heathridge Manor." Where to begin with her? Arm chopped off by her insane mother, forced to help her insane brother kill people, and at the end of episode it's revealed that [[spoiler:she herself has gone insane from all the trauma she's experienced... [[MaybeMagicMaybeMundane or perhaps her house is evil]]]].
* Bruce Morrison, from the Season 8 episode "All That Remains". [[spoiler:When your older daughter takes advantage of your potential mental disorder to frame you for DomesticAbuse, murders your wife, murders your younger daughter, and then further uses your mental state to frame you for both murders, all because [[ItsAllAboutMe she believed her younger sister was stealing attention from her]], you KNOW you're this.]]
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