* ''ComicStrip/{{Candorville}}'' was once a mostly realistic strip with the occasional BigLippedAlligatorMoment. Its [[GenreShift transition]] into a darker, more unnerving brand of humor can be traced back to the first time [[BlackAndNerdy Lemont]] and [[KnifeNut Saxon]] are alone together, when Saxon's mask of sanity begins to slip. Two lines cemented the change, and every subsequent plot arc can be traced back to them: "[[spoiler:The vampire, Roxanne, is not my lover. She's my mother.]]" Of course, this was aided somewhat by [[spoiler:Saxon's suddenly developing MilkyWhiteEyes and fangs]].
* ''ComicStrip/FunkyWinkerbean'': "That's because I was the one sending those texts to you."
* ''ComicStrip/ForBetterOrForWorse'': "I have fallen in love...but it's not with a girl."
** When Elly is informed after getting back from vacation that Kourtney has been fired in her absence.
* ''{{ComicStrip/Pogo}}'': "We have met the enemy, and he is us."
* From ''ComicStrip/{{Drabble}}'':
-->'''Norman:''' I never thought to ask you, Echo, what are you doing at this wedding?
-->'''Norma/Echo:''' Oh, I'm related to the bride.
-->'''Norman:''' What a coincidence. I'm also related to the bride.
-->''Cue simultaneous OhCrap looks.''
* {{ComicStrip/Retail}}: A challenge is declared. A plot to make a rival change jobs backfires horribly.
-->[[TheSlacker Cooper]]: *To [[InsufferableGenius Josh]]* Because, by this time next year, I'm going to have your job.
* ''ComicStrip/{{Garfield}}'': When Jon [[http://garfield.com/uploads/strips/2006-07-26.jpg confronts]] Liz on going out with another guy:
-->'''Liz's date:''' So, what a minute... you ''like'' this guy?\\
'''Liz:''' As a matter of fact, I do.\\
'''Jon:''' That's right! She does! ...You do?
* ''ComicStrip/CalvinAndHobbes'': "[[AdultsAreUseless Okay, quitter! Go home.]]"
* ''ComicStrip/BloomCounty'' sometimes had these, and usually played them for laughs.
-->'''Fundamentally Oral! Bill:''' ''[[DoesThisRemindYouOfAnything PENGUIN LUST!]]'' Nothing but urges from ''HELL!''