[-[[caption-width-right:300:From left to right: Bubbles, Blossom, and Buttercup]]-]

->''"Sugar... spice... and everything nice. These were the ingredients chosen to create the perfect little girls. But Professor Utonium accidentally added an extra ingredient to the concoction: Chemical X! Thus, the Powerpuff Girls were born! Using their ultra-superpowers, Blossom, Bubbles, and Buttercup have dedicated their lives to fighting crime and the forces of evil!"''
-->--'''The oh-so-InteractiveNarrator'''

One of Creator/CartoonNetwork's most popular [[CartoonCartoons original series]], originally called "The Whoopass Girls" by creator Creator/CraigMcCracken (they were created with "sugar, spice, everything nice," and a can of Whoopass) before it got picked up by the network during TheRenaissanceAgeOfAnimation. ''The Powerpuff Girls'' centers around a PowerTrio of {{Little Miss Badass}}es who fight crime in the fictional city of Townsville. These ArtificialHuman girls, who have no fingers, toes, ears, or noses, were created when Professor Utonium accidentally added Chemical X to his mixture of sugar, spice, and everything nice.

The series' heroes are Blossom, "commander and the leader," who often acts the DrillSergeantNasty; Bubbles, "the joy and the laughter," whose personality is very similar to that of her namesake from ''{{Jabberjaw}}'' (but not quite a DumbBlonde), and Buttercup, "the toughest fighter," and a tomboy with a bad attitude. Their simian ArchEnemy Mojo Jojo wears a helmet to cover his enlarged brain and speaks in a manner [[IntentionalEngrishForFunny reminiscent of bad anime dubbing]]. Aside from the obvious {{Anime}} influences, most of the series' supporting characters are drawn in the style of ''WesternAnimation/TwoStupidDogs'' (not surprisingly, as the creator of the show worked on that cartoon).

The series gained notice from Cartoon Network in the same way that ''WesternAnimation/DextersLaboratory'' did, via the WhatACartoonShow contest for nonprofessional animators. It's possible that the two series have a SharedUniverse; the animation is very similar, the creators for both series collaborated on both series, and [[ShowWithinAShow "TV Puppet Pals"]] and superheroes like Major Glory and Val Hallen appear in both series.

Warner Bros. released an [[TheMovie animated feature]], ''WesternAnimation/ThePowerpuffGirlsMovie'', in 2002 (which bombed at the theaters, likely due to a severe decline in popularity that began in early 2001). A comic book series (from ''DCComics'' no less). An {{anime}} version, ''Anime/DemashitaPowerpuffGirlsZ'', hit the airwaves in Japan on July 1st, 2006.

Ten years after the show ended (and four after ''Powerpuff Girls Rule'' special). The series came back in the form of a CGI special in 2014. Most likely as a test pilot for a reboot (though oddly this was ''after'' Craig had left Cartoon Network to work with Disney on ''WesternAnimation/WanderOverYonder'', and even before then he has left the show after season 4). Supporting this is the that [[http://read.idwpublishing.com/Powerpuff-Girls/comics-series/11436 the girls returned to comic book format in September 2013]], this time under the IDW brand as part of a deal to allow classic Cartoon Network cartoons to be told in new adventures. Sure enough, [[http://www.eonline.com/news/551366/the-powerpuff-girls-returning-with-new-series-on-cartoon-network a brand new series was announced for a 2016 release]].

[[Characters/ThePowerpuffGirls Now has a character sheet]].

[[Recap/ThePowerpuffGirls There is also a recap page that would appreciate some assistance]].

Now with its own [[ComicBook/ThePowerPuffGirls comics page]].

The Girls and Mojo are set to appear in the IDW CrisisCrossover comic book event ''ComicBook/CartoonNetworkSuperSecretCrisisWar'' in June 2014.

!![[CatchPhrase The series of The Powerpuff Girls!]] Provides examples for:

* ThePowerpuffGirls/TropesAToI
* ThePowerpuffGirls/TropesJToQ
* ThePowerpuffGirls/TropesRToZ

[[TheStinger The Internet]], [[TVTropesWillRuinYourLife Tropes, and all of the dopes. These were the ingredients chosen to create the perfect life ruiner.]]