A mid-1990s cartoon based on the infamous ''Mutant League Football'' and ''Mutant League Hockey'' games by Electronic Arts depicting monsters playing pro sports.

An earthquake at a football stadium reveals a cache of illegally dumped toxic waste which mutates all the spectators into half-human abominations. Soon a pro sports league springs up around the mutants, and rather than make the big bucks, rookie athlete Bones Justice decides to play for his dad's team, the last-place Midway Monsters.

Despite [[FamilyUnfriendlyViolence surprisingly graphic violence]] [[WhatDoYouMeanItsForKids for being aimed at young viewers]], ''Mutant League'' managed to last two seasons, the second longer than the first.

* AffirmativeActionGirl: The second season introduced us to Thrasher Malone, the show's first female mutant.
* BrokenAesop: In one episode, evil mutants try to trick some adolescent fans into jumping into toxic waste to mutate themselves and be more like their idols in the League. The kids hesitate because "norms can't mutate". The very existence of the Mutant League is proof that isn't true. Everyone in it--from the players, refs, coaches, team owners, play-by-play guy and various mutants who had nothing to do with the League--''were'' ordinary humans once upon a time. Trying to mutate yourself wouldn't be an easy or smart thing to do, sure. But obviously it can be done.
* {{Catchphrase}}: Two, spoken by Bob Babble: "[=UN-BEE-LEEEV-able=]!" and "OOOOH! ThatsGottaHurt!"
* ChristmasEpisode: Same thing as Literature/AChristmasCarol, but [[YetAnotherChristmasCarol no ghosts]].
* CorruptCorporateExecutive: Commissioner Zalgor Prig constantly tries to [[DisproportionateRetribution kill Bones for not agreeing to play for his team]], the Slaycity Slayers.
* DentedIron: The Monsters' coach is a former player who suffers from a degenerative disease that prevents the rejuvinator from healing injuries fully, he is now left a wreck as all of the injuries he sustained have caught up to him.
* DisappearedDad: Bones' father mysteriously disappeared, and a subplot that never really went anywhere was Bones' quest to find him.
* EveryoneCallsHimBarkeep: Zalgor's main thug is named Thug.
* GoodThingYouCanHeal: Although players' arms, legs and heads were frequently knocked off, they could usually come out good as new by bathing in a machine called the rejuvenator. As a couple episodes showed, though, there were things it couldn't fix.
* MerchandiseDriven: There was an almost-unknown line of action figures released based on the show. Had there been a third game in the series, ''[=GamePro=]'' magazine implied it probably would've been based on the show rather than the games already in existence.
* PokemonSpeak: Moe and Spewter. Of course, they are so dumb that all Moe can say is "Eat dirt," and all Spewter can say is "Dead meat."
* ThatsGottaHurt: Often shouted out by Bob Babble whenever a player gets injured.
* TrademarkFavoriteFood: Zalgor's is live spiders.
* VocalDissonance: Bob Babble, the game commentator, who can describe the events of the games the teams play, all the time that his voice is always high-pitched and sounds like the vocal screams of game commentators when they cheer. Mostly the best part is that whenever one player gets injured in a gross way, Bob would often shout out his famous {{Catchphrase}}: "OOOOH! ThatsGottaHurt!"
* WithMyHandsTied: Discussed and parodied in the Season 2 episode "Enter the Skeletoid", when Razor Kidd tells the strong {{Badass}}, "I can beat you with one hand tied behind my back!" Of course, the strong guy rips off Razor's arm as a literal response, and the latter snaps back, "Hey! I said ''tied!''" Razor even tries to kick the strong one, who quickly rips off his leg as well!
* YourHeadASplode: The unfortunate side effect of a machine in one episode that makes players super-strong. Not that it's worse than anything else that happens to the mutants, mind.