[[WMG: ''Y: The Last Man'' is a prescient LetsPlay PerspectiveFlip of a more customizable ''VideoGame/{{Pandemic}}'' clone or sequel.]]
It makes perfect sense. In the hypothetical Pandemic 3, the Player set up a Y-chromosome linked virus and was very, very careful to limit as many symptoms as possible. Then, after building up its Infection rating to the maximum level, giving the disease enough time to spread to the entire world (including [[ThatOneBoss Madagascar]], but not including the [[BonusBoss International Space]] [[BraggingRightsReward Station]]), and saving up a couple dozen Evolution Points, the Player upgraded it to include vomiting, bleeding, ulcers, and hemorrhagic fever. The plan was to [[AwesomeButImpractical give it an X-chromosome fatality effect after another thirty or fifty evolution points]]. Yorick and & were a result of getting the OneInAMillionChance immunity score, like how the [[BoringInvincibleHero Master Ball]] in the first two generations of Franchise/{{Pokemon}} fails 1/65536 times due to how the RandomNumberGenerator works.

[[WMG: The disease was the result of a godly intervention that decided, because several signs and possible causes happened at once, it/they/he/she [[ForTheLulz may]] [[ForTheEvulz as]] [[ForScience well]] set off the Gendercide.]]
[[WatsonianVersusDoylist From a Doylist perspective]], this is absolutely correct, though with effect and cause reversed.

[[WMG: Agent 355's real name]]
I'm sure I'm not the first person who thought of this, but I have a good idea of what 355's real name is. From how Yorick says "it's perfect", and the word [[spoiler:Peace]] on [[spoiler:her grave marker]], her name is probably [[spoiler:Irene, derived from the Greek for 'peace']].

[[WMG: Yorick has magic powers]]
He's a little too insistent about how much he sucks at everything, it could just be covering up. And he gets his levitation trick names mixed up because he's only pretending to use tricks. His skill at annoying people comes from everyone sensing something wrong with him, and he seems to make animals nervous. But mostly he's just way too good at disappearing in thin air. (And he never does explain that trick to 355.)
* Also explains his preternaturally bad brawling skills: He's a SquishyWizard.
* And come to think of it, how on Earth did he track 355 down to a random location in Paris in the same time it took him to run there from Beth?
* And over the course of the series, he gives himself a hyperactive brain, an enlarged heart and even a ride in a submersible steel balloon. The parallels to ''TheWizardOfOz'' are obvious!