[[WMG:The ending will be [[BittersweetEnding bittersweet]] or a [[DownerEnding downer]].]]
This is a DarkerAndEdgier work, right? So, depending on your choices, it could be either of them.
* [[spoiler: {{Jossed}}--it does seem to end pretty happily for both Spider-Men.]]

[[WMG: Anti-Venom won't be [[LyingCreator the killer]].]]
I'm just saying Anti-Venom looks like a really generic choice for the killer of Spider-Man. I guess it'll another more minor super villain.
* He's been confirmed to be killer. The reason he was picked was because he drains Spider-Man out of his powers, and then kills him. However, with a changed timeline, there could always be more than one villain attempting to kill him....

[[WMG: Amazing will die more than once.]]
Hey time travel is involved and with that strange things tend to happen...

[[WMG: A version of the Sinister Six will appear.]]
Compromised of villains from the present and the future.
* [[spoiler: {{Jossed}}--the only mention of the Sinister Six is one of the unlockable newspapers.]]

[[WMG: The next ''ComicBook/SpiderMan'' game will take place in its own universe.]]
And it will [[AdaptationDistillation throw in various aspects of the mythos coherently]], unfortunately, the final mission would be a brand new rendition of ''[[DownerEnding The Night Gwen Stacy Died]]''.
* {{Jossed}}--unless something else comes out before it, the new game will be a tie-in to ''Film/TheAmazingSpiderMan''.
** It's a tiny bit more complicated than that. While the universe is in the one for ''Film/TheAmazingSpiderMan'' Beenox still has a lot of freedom in how the game's story is and the origins of villains. So it might as well be in its own universe.

[[WMG: There's a reason there is no mention of Shocker at all.]]
Notice how he doesn't appear in the campaign or newspapers at all, and yet the henchmen in the present use weapons like his gauntlets. The reason is that Sloan employed Shocker to make weapons for the company.
* Alternatively, it could be that they kept him out of the game to prevent 2099 from saying "Shock" ''even more'' than necessary.

[[WMG: Spider-Man 2099 actually ''does'' date Overdrive 2099]]
Based on the DS version, 2099 Spiderm-Man and Overdrive do indeed date, but it they instead have a Black Cat/Spider-Man type of relationship. Whether they would go further that is improbable.