[[WMG:The Red-face Pox made it across to the mainland and has {{Gendercide}}d the planet by the time of Chapter 1]]
The odds of a carrier fleeing the plague making it across the Sea of Japan before the order to seal the borders are pretty good, and once it got going in China[=/=]Korea it is a matter of time before all of Eurasia is hosed.
* On Blessed Kasuga's orders, the stage management of the [[http://en.wikipedia.org/wiki/Dutch_East_India_Company VOC]]'s contact with the shogunate has succeeded in concealing the lack of Japanese men from the Dutch sailors. Like the Inner Chambers (which are used for the Kapitan's annual audience with the shogun), Deshima has an unusually high male population to help maintain the facade...but even there many of the men are either past their breeding prime or are actually women in drag like [[spoiler:Gondayu]].

[[WMG: [[StatusQuoIsGod Status quo will become God]], the male population will slowly climb back to normal levels, and men will take back the power.]]
Culminating in the Meiji Restoration.
* Certainly, Yoshimune has decreed physicians to find a cure for the Redface Pox. If that is cured then it's a matter of building up the population.
** I think I have to amend this WMG: based on reports that the mangaka wanted to end at Volume 10, the front cover (if Amazon is to be believed) has many people instead of just one (which makes me think it's the GrandFinale), and Harusada (daughter of Yoshimune's youngest daughter, and historically will provide Ieharu's heir) has at least one ''son'' (that is seen anyway), it's possible that the pox will end right around the time the male Ienari takes power. (Without being able to read Japanese though, I wouldn't be able to confirm or deny it though.)
*** Which is just as well, really, while it'd have been symbolic to make status quo become God at the Meiji Restoration, as of volume nine we're only two shoguns away from Commodore Perry forcing Japan open at gunpoint. It'd have to be restored by then or else the Americans wouldn't think twice about forcing Manifest Destiny on them and that's too wildly Alternate Timeline, even for Ooku.
* Two Points.
** Given that "Women's Work" is at this point is "Everything but Dutch Medicine and perhaps soldiery" there is a lot of inertia to overcome if anyone seeks to restore [[StayInTheKitchen pre-plague-patriarchy]]. Things will get more egalitarian than the current LadyLand, but the governing classes are not going to conveniently die off.
** More to the point, even if the rest of the world dodged the proverbial bullet in terms of the Red-Faced Pox, the opening of Japan will smack the rest of the world with a virgin field epidemic almost tailor made to shatter the Imperial Powers of the age.
*** Fair points to both. To address the former...perhaps population status quo is restored by the time Perry shows and patriarchy restored by the Meiji Restoration? And as for the latter that does bring to mind something: we only have a Dutch captain's word that the rest of the world is unaffected, and for all we know, he could have left the Netherlands right before the Redface Pox hits. If the pox started in bears that spells trouble cause unless this is a species of bear exclusive to Japan, it could spread to other bears before it hits humans, and all it would take is one bear or infected human to make it to the mainland to spread it. For all we know, ALL of the world got poxed. Which brings me to my ''new'' WMG.

[[WMG: The manga will end with Commodore Perry arriving...and Perry will be a ''woman''.]]
Turns out Japan had nothing to worry about regarding conquest: the Redface Pox was a worldwide epidemic and women are the dominant gender around the world.