[[quoteright:234:[[ComicBook/{{Thanos}} http://static.tvtropes.org/pmwiki/pub/images/thanos_5540.png]]]]

* Allfather Starr towards the end of ''{{Preacher}}''. The abuses and mutilations he suffers over the series in pursuit of Genesis take a heavy toll, to the point where the final story arc has him pointing a gun at the mirror and saying "Doom cock" over and over again [[spoiler: and gassing his advisors when they say they're abandoning the pursuit of Jesse Custer]].
* ComicBook/{{Venom}} (Eddie Brock), in an issue of SpiderMan, suffers a villainous breakdown after he recieves a touch of death from another villain. Eddie Brock is unharmed as his body is protected by the symbiote but the symbiote itself seemingly dies as it melts into a lifeless, motionless, puddle. Brock, who up to this point has lost everything and now the only friend he had is dead, breaks down and cries for his fallen partner. Even Spider-Man, who has been stalked and tormented relentlessly by Venom, can't help but to feel sorry for Brock. However, the symbiote would soon recover.
* Kingpin in ''ComicBook/UltimateSpiderMan''; after being completely in control through the entire series, manipulating everyone and getting away with murdering someone with his bare hands and taping it, his schemes are thwarted by [[spoiler:Daredevil holding the only thing he cares about, his comatose wife, hostage]]. As he's on the way to a flight to leave the country, he has a VillainousBreakdown during which he orders his henchmen to ''bomb a high school while it's in session''.
** The further bitter irony here is that the ordered bomb is intended to kill Spider-Man... [[spoiler:when it was Spider-Man who talked Daredevil down from killing Kingpin's wife out of sheer desperation, thus saving her life.]]
** Kingpin's first story arc in ''ComicBook/UltimateSpiderMan'' also played this trope for laughs. After spending several issues as a smug, collected crime boss, he's reduced to a screaming, enraged fit when Spider-Man attacks him with a barrage of [[YouAreFat "You're so fat" jokes.]]
* Riddler has a rather nice one in ''ComicBook/BatmanGothamAdventures'' #11. After escaping Arkham he decides that the best way to beat his urge to commit crimes and leave riddles (thus guaranteeing that Batman will eventually catch up to him) is to solve crimes himself and leave Batman riddles pertaining to ''them''. After catching several wanted criminals thanks to the Riddler's hints (which you'd think would be convenient enough that he wouldn't be in such a hurry to end it), Batman figures out that all the clues contain part of a hidden riddle which leads him right to Riddler. Upon learning that his psychosis is so deep that he left Batman a clue without even realizing it, Riddler freaks out, screaming about how impossible it is. Then he comes to his senses:
-->"You don't understand... I really didn't want to leave you any clues. I really planned never to go back to Arkham Asylum. But I left you a clue anyway. So I... I have to go back there. Because I [[TheWoobie might need help]]. I... ''I might actually be crazy''."
* In ''Comicbook/SupermanBatman'', when [[PresidentEvil President]] Lex Luthor's scheme to smash a Kryptonite asteroid into the Earth fails, Luthor (who was the U.S. President at the time) uses a variant combination of the "super-steroid" Venom (a chemical associated with the Batman villain Bane), liquid synthetic Kryptonite, and an Apokoliptian battlesuit to go on a violent rampage. This, unsurprisingly, gets him impeached.
** He gets a worse one in a recent story in ''ComicBook/ActionComics''. After traveling across the planet and in space in an attempt to regain something like the Orange Lantern Power Ring, Luthor gains the powers of a creature from the Phantom Zone and proceeds to use it to torture Superman. Once he finds out that Superman is Clark Kent, though, he ''loses it''.
** Then there's the time Lex ends up getting his hands on [[AGodAmI incredible cosmic power]], and manages to make the universe perfect for a few minutes. He swiftly learns, however, that in order to cement this power, he must let go of all the hatred in his heart... including his hatred for Superman. Supes, being Supes, begs him to let go of their old grudges. Lex's response? "'''YOU ''DARE'' TO LECTURE ME?'''" And thus was universal bliss ended.
* The second Sabbac over in DC Comics is constantly just on the edge of this. Most of the time he's calm, cocky and sarcastic. But when he doesn't get what he wants, when things don't go his way, he loses it entirely, screaming and ranting as he kills friend and foe alike. Imagine a greedy ten year old with the power to destroy a small nation and you've got Sabbac.
* In [[ComicBook/SonicTheHedgehog Archie's Sonic the Hedgehog comic]], [[spoiler:Dr. Eggman]] began to suffer mentally as a result of the constant defeat at Sonic's hands. This finally came forward after his latest defeat, which turned him into a babbling madman. He spent the next few issues in a padded cell, wearing a straitjacket.
** If you read the issue, its art suggests that Snively is [[WhatTheHellHero calling Sonic out]] for putting [[spoiler:Dr. Robotnik, or Eggman if you prefer,]] in that condition to begin with.
*** As well, despite snapping himself out of it, [[spoiler:Dr. Eggman]] has yet to really recover from the moment, going so far as to [[spoiler:leave the Freedom Fighters to grieve at Antoine's seeming death instead of wiping them out right then and there.]] It pisses Snively off so much he pulls a ScrewThisImOuttaHere and decides to handle things ''his'' way again. However, it's hinted that this is not Eggman not recovering, but his subordinates not realizing that using the same tactics over and over is not a good idea.
*** Fleetway's SonicTheComic Dr. Robotnik did it about 8-9 years earlier, for much the same reasons. During the Sonic Adventure storyline, he cracks and goes from wanting to conquer the world to just flat-out destroying it because he sees it as the only way to rid himself of Sonic.
** [[EvilTwin Scourge]] also qualifies. After being betrayed by The Supression Squad and ganged up on by everybody, he declares that he's going to spin dash both Mobius and [[MirrorUniverse Moebius]] in half, simply because he can.
* This was the premise of the ''{{Thunderbolts}}'' "Caged Angels" arc by WarrenEllis. A group of incarcerated telepaths drive each member of the [[AntiHero already]] [[VillainProtagonist unstable]] team over the edge (Except for Bullseye, who can't get any crazier.) The best one is NormanOsborn, starts walking around naked ranting about what he'll do when he's president and how much fun killing people was.
** "Norman will do what it takes, he won't mind. Norman will make [[TheGwenStacy the girl]] [[RetCon pregnant]] then [[NotTheFallThatKillsYou snap her neck in public]]."
** It gets [[CrowningMomentOfAwesome even better]] when he finally gives in and becomes the Goblin again.
--->'''Swordsman''': ...mother.
--->'''The Green Goblin''': YOU DIDN'T HAVE A MOTHER! A pig coughed, and you fell out!
** Later comics in "Comicbook/DarkReign" made it pretty clear that for all Norman's VillainWithGoodPublicity act, he was most of the time a hop, skip and jump away from a full psychotic breakdown. And having to maintain a good public reputation as the head of the Initiative only helped slowly push him closer to one. As was particularly cruelly lampshaded in a BreakingSpeech delivered to Norman by the Molecule Man, it was a default position amongst the main players of the Marvel Universe that it wasn't not so much a question of "Will Norman crack under the strain?" as "''When'' will Norman crack under the strain?" Several of them were waiting for his breakdown since he first took power.
** It finally happened in ComicBook/{{Siege}} #3. Though after all the buildup it was given, and the ''masterful'' snap he had in Thunderbolts, readers found this one ([[spoiler:a painted up face, jeans and a t-shirt under the armor, and nonsensical babbling about how his plans to save everything from the Void had been ruined]]) more than a little underwhelming. The part ''before'' that ([[spoiler: where he flat-out orders Sentry to bring down ''the entire floating city of Asgard'']]) was much better.
** Even before Dark Reign and Thunderbolts Norman was suffering from breakdowns much more often.
*** Some of them weren't even real breakdowns. A few times it was just Loki using his magic powers to make Norman think he was hallucinating.
*** For Osborn, the Goblin ''is'' a villainous breakdown. When the cool, collected VillainWithGoodPublicity and master of [[GambitIndex every gambit in the index]] has his plans go off the rails and he reaches the point that he starts screaming and ranting and cackling and throwing pumpkin bombs, you know it's all over. He wasn't always portrayed this way (once it was decent Osborn having the PsychoSerum take over, and he'd be defeated and forget he was the Green Goblin until next time.) Of course, the truth of the situation in Osborn's head is that Osborn on a good day is about as sane as the Joker on a ''bad'' day, and he can only act otherwise for so long. When the situation goes off the rails, this ability is strained.
* Happened to Magog in ''ComicBook/KingdomCome'' when he was finally confronted by {{Superman}} in the ruins of Kansas. Immediately followed by a VillainousBSOD.
** It's implied that the breakdown had been building (and was maybe already in progress) since he destroyed Kansas, it's just that Superman's arrival is what tipped it over.
* In ''StarWars Knights of the Old Republic'' Arkoh Adasca and Haazen suffer breakdowns right before meeting their deaths; Arkoh goes from Suave Buisnessman in complete control to a gibbering lunatic screaming at his men to murder the heros and daring the man he abused into smiting him in an extremely nasty karmic death, and Haazen is reduced from Magnificent (if smug) bastard to a helpless wretch who can only stammer and beg Lucien not to use the McGuffin to thwart his plans and kill him in the process. Demagol also looes his coherence and stutters, and Raana completely loses her mind.
** And in StarWarsLegacy, Darth Krayt suffers a protracted one across several issues after [[AntiHero Cade Skywalker]], the one man in the galaxy who can cure his chronic illness, escapes his grasp. [[spoiler: It gets so bad that his previously loyal [[TheDragon Dragon]], Wyyrlok, decides to kill him because he's now a liability to his own cause]].
* [[UltimateMarvel Ultimate]] Magneto suffers a breakdown at the climax of ''{{Ultimatum}}'' when Jean Grey shares Nick Fury's memories with him and he learns that [[spoiler: the existence of mutants was just an accidental byproduct of a SuperSoldier experiment]]. This information shatters Magneto's delusions of grandeur and he completely loses the will to fight.
* Joe Dalton tends to go through one of these whenever someone mentions the name ComicBook/LuckyLuke in his presence. Usually inverted, as it tends to happen at the beginning of an episode, and as soon as he regains his calm, he devices a plan to break out of the CardboardPrison, starting the plot.
* In the recent Garth Ennis ''ComicStrip/DanDare'' mini-series, the Mekon uses his grand finale battle with Dare to vent some long pent-up grievances:
--->'''Mekon''': Dare!! Before you came, my rule was ALL! My word was law! My realm was a place of [[StrawVulcan cold and perfect logic]]! But my time has come again! I'll burn your world and take your race as chattel! [[DisproportionateRetribution I'll make a goblet from your skull! I'll fill it with your blood!]] And every day! Every day! I'll drink a toast! ''To the Earthman who taught the Mekon how to hate''!
* SelfDemonstrating/TheJoker suffered a truly epic one in ''ComicBook/EmperorJoker''. Let's recap: He steals [[GreatGazoo Mxyzptlk's]] powers, turns the ''entire universe'' into his playground, begins the [[EndOfTheWorldAsWeKnowIt end of Time, Space, and Existence]], and he tears Superman's heart out and eats it. [[spoiler: As he lies dying, Superman dares Joker to kill Batman. Joker does so, but right after he does, Batman reappears, good as new. Confused, Joker tries it again and again, growing increasingly frantic as Batman repeatedly comes back, going as far as to [[BreakingTheFourthWall beg the writers and artists to let him finish Batman off]]. Superman [[BreakingSpeech taunts him, revealing that despite having all that power, Joker is still nothing but a clown, unable to do anything useful with his life and needing Batman to have any purpose at all]]. As Joker breaks down, Mxyzptlk uses the opening to take his powers back and fix everything.]]
** Before that, Joker loses his temper when he uses his RealityWarper powers to torture Superman, but Supes won't go crazy or slip past the DespairEventHorizon no matter what he does.
-->'''Joker''': (''some torture, Superman kills himself on purpose to deny Joker's fun'') '''What!?''' That's not the way I wanted this to end! I don't want the big lummox ''dead'', I want him broken!
-->(''brings Superman back to life, more torture'') Phooey! Phooey! '''Phooey!''' To hell with this stupid broadcast! No one is following the script! I want everyone back the way they were before! '''Phooey!''' Superman wasn't '''breaking!'''
** A truly heart-wrenching LegendsOfTheDarkKnight story titled "Going Sane" recounted how an epic fight between the Joker and Batman ended in the Dark Knight's (apparent) death. ''Victory'' freaked out the Joker so badly that his then-current personality...dissolved. Melted away, leaving a sweet, gentle man who loved old-time radio comedy and who pondered "finally getting something done about this skin condition..." By the end of the story, one actually felt ''sorry'' for the Joker!
** He also suffers from this in Brian Azzarello's ''{{Joker}}''. You can see it briefly when he trashes the bar after Harvey Dent doesn't take his phone call, but he finally reaches breaking point at the end when [[spoiler: Batman turn his BreakingSpeech back on him, causing him to fly into a blind rage and shoot his own loyal henchman.]]
* Dirk Anger of ''{{Nextwave}}'' spends the entire series going through a nervous breakdown. He thinks nobody noticed.
* Long-time ''JusticeSocietyOfAmerica'' foe Vandal Savage had a rather pitiful breakdown during One Year Later when faced with the possibility of imminent death for the first time in his millennia long lifetime.
* [[BigBad Overlord]] from ''ComicBook/TransformersLastStandOfTheWreckers'' has the more subdued version. He's a nigh-unstoppable Decepticon [[DangerousDeserter deserter]], whose main motive for desertion (or anything) was to goad Megatron into a one-on-one fight. He takes everything the Wreckers throw at him, [[spoiler: even getting reduced to a burning endo-skeleton]] and keeps going... until [[spoiler: Verity tells him that Megatron is dead, and the fight he spent his entire life preparing for will ''never happen''. After that, he doesn't even put up a fight as they cart him off to prison.]]
* In ''YTheLastMan'', the opium smuggler Yorick befriends and falls for on the journey to Australia justifies her trade by reasoning that humanity is already doomed, and all she's doing is making people's lives easier by giving them an escape from this awful knowledge. Then, she [[HeelRealization realizes]] that Yorick's survival means that humanity has hope after all, and all she's done is make things worse by creating further misery and despair. [[DrivenToSuicide She doesn't]] [[RedemptionEqualsDeath take it well]].
* During ''[[Comicbook/{{Legion of Super-Heroes}} Legion of Three Worlds]]'', [[{{Superman}} Superboy-Prime]] was a relatively composed SmugSuper ''until'' he realized the Legion planned to bring [[TheFlash Bart Allen]] back to life. Bart is the one person in the universe who Prime actually fears, so he completely flips his lid when Bart returns.
* This happens to {{Sinestro}} in GreenLantern throughout BlackestNight, more than once. Sinestro, by his [[KnightTemplar nature]], is big on Authority being competent in their actions. So every time he learns new evidence that the Guardians Of The Universe are [[NeglectfulPrecursors very, very, very, very incompetent]], he gets... a little upset. It's even worse for him because reminds him how the Guardians painted [[OnlySaneMan Abin Sir]] as a CloudCuckooLander for daring to expose said incompetence.
* SelfDemonstrating/DoctorDoom suffered a pretty huge one in one story. At one point he had Reed Richards imprisoned in a torture room full of mirrors placed in such a way that the warped reflections would drive anyone crazy. At the start, he's classic arrogant gloating Doom. By the end of the story a few issues later, he's beating the crap out of Reed while screaming and ranting about how much he hates Reed. The fight takes them to the torture room, and Reed removes Doom's mask. Seeing thousands of warped reflections of his own scarred face drives Doom insane.
* In the ''SpiderMan'' storyline ''ComicBook/EndsOfTheEarth'', it's revealed that the dying Doctor Octopus' grand scheme is to [[spoiler:wipe out most of humanity, leaving about 0.08% of humanity to live and rebuild, remembering him as the greatest monster that ever lived]]. However, Spidey points out a glaring flaw in that plan: [[spoiler:yes, 0.08% of humanity would live on - but his super weapon would flash fry their brains, leaving them brain dead.]] Faced with that glaring flaw, Octopus flips out, trying to see where he went wrong, giving Spidey the opportunity to take him out.
* All of the Inner Circle by the end of ''{{X-Force}}: Necrosha'', including the sympathetic members, have devolved into raving lunatics giving [[EvilIsHammy hammy speech after hammy speech]] about how they're going to kill everyone on Earth and remake it in their image.
* At the end of ''{{Comicbook/Hellboy}}'': ''Conqueror Worm'', even though all his plans have failed and he is now nothing but a ghost, Rasputin still believes that he will be the one to release the Ogdru Jahad and bring about Ragnarok. However, he is confronted by the godess Hecate, who bluntly [[BreakThemByTalking tells him that he is completely insignificant in the grand scheme of things,]] that Hellboy is the only one with the power that he seeks and that, even after summoning him to Earth, he has no control over him. Rasputin flies into such a rage that he appears to be on the verge of attacking Hecate before she obliterates him with a wave of her hand.
* In the crossover ''ComicBook/SpiderMan / Franchise/{{Batman}}'', Carnage has a spectacular one. Near the end of the story, he has Batman at his mercy and Spidey unable to act. Then, SelfDemonstrating/TheJoker reappears holding a Jack-In-The-Box and ready to pop it open and unleash a deadly virus, ''[[TheOnlyOneAllowedToDefeatYou all because he won't let anyone else kill the Batman]]''. Carnage, a mass murderer himself, flies into a magnificent panic and giving Batman the opening to free himself and take him down and allowing Spidey to stop the Joker.
* Both Bane and Az-Bats suffer this during the ''ComicBook/{{Knightfall}}'' storyline. For Bane, the appearance of the Jean-Paul Valley Batman hadn't concerned him much, but after he was badly wounded, Bane decided to put this pretender to the throne out of his misery. Once JP is able to deliver a strike that severed his Venom feed, Bane panics and finds himself being kicked around and ultimately defeated. For Az-Bats, he was already suffering from SanitySlippage thanks to the hallucinations of his father and Saint Dumas, but once he ends up letting Abbitoir die, he's finally lost it, ranting and raving how he's the one true Batman and that he hadn't failed in his "sacred mission".
* {{Thanos}} tends to go nuts whenever anything endangers his relationship with Death. He stammers in disbelief when he realizes that the Power Infinite has made him ''too'' powerful to be with Death[[note]]he had to be ''equally'' powerful to Death, not ''more'' powerful[[/note]], giving the heroes the opportunity to stop him. He throws a fit of jealousy and curses Deadpool with immortality when it seems like Death likes Wade better than him. Finally, when he learns that his ThanatosGambit in ''TheThanosImperative'' has rendered him immortal, meaning he can never be with Death, he loses all of his sanity and becomes so dedicated to destroying everything that he has to be sealed in another universe to stop him.
* ComicBook/TheRiddler has a grand one when he decides to deal with [[TheFlash Impulse]]. After a bad encounter with TheFlash and Comicbook/{{Robin}}[[note]]Riddler had bailed from Gotham following the events of ''ComicBook/BatmanNoMansLand''[[/note]], Edward heads for Manchester to deal with Impulse, thinking he can easily outwit the protege of the Scarlet Speedster and one of the Boy Wonder's closest allies. Instead, poor Eddie is left a blabbering mess with Bart utterly ignores every sign that the Riddler wants him (too busy playing video games), Bart's inability to recognize who he was (he mistakes him for TheQuestion, Mr. Freeze and Abra Kadabra), outwitting his traps without thinking (before he's done reading off his first clue, Bart comes back with the bombs by looking under every porch in town. And finds his other bombs while he was at it!) and ultimately saves his captives by retaping his last clue that he tore up. His comment after revealing the second set of bombs sells it, though:
-->'''The Riddler:''' "'''DO YOU THINK ''MERE'' SPEED CAN UNDO MY GLORIOUS INTELLECT? YOU'RE ''WRONG'', I TELL YOU! WRONG, WRONG, ''WRONG!'''''"
* Monocle in ''ComicBook/ForeverEvil'' out of paranoia. More notably, though, is Lex Luthor whose fears about super-humans come to life with the Crime Syndicate, and finally calls out for Superman's help.
* Like all villains created by Goscinny, ComicBook/{{Iznogoud}} is particularly susceptible to it. The fact he lives in a Palace where he (a megalonaniac aggressive EvilChancellor) seems to be the [[OnlySaneMan only one with some degree of sanity]] doesn't really help.
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