[[quoteright:280:http://static.tvtropes.org/pmwiki/pub/images/madagascar.jpg]]
[[caption-width-right:280:[[CrowningMomentOfAwesome Did I just hear the Hallelujah Chorus?]] [[FridgeLogic Wait, how can Madagascar close its NON-EXISTENT airport?]]]]
A web game developed by Dark Realm Studios that simulates destroying the world with [[ThePlague your very own disease]].

The game randomly picks your starting location. Previously to that, you had to pick your bioweapon: parasite, virus, or bacteria, each with their own set of advantages and disadvantages. Over time, you get points for infecting people and killing people with your bioweapon. These points can be spent adding various attributes to your virus, like symptoms, resistance, and new means of transmission. This can make your virus more lethal, more contagious, more powerful, but more visible. On the other hand, the governments of said infected countries will do their best to stop the spread of your bioweapon: burning corpses, killing carriers, etc.

Sound easy? Not so much. You'll know you're doing well if you infect these countries:
* Peru (Will often close its borders.)
* Greenland ([[{{Determinator}} Has a hospital that refuses to give up.]])
* Mexico ([[HarsherInHindsight Oddly hard to infect.]]) [[invoked]]
* China (Takes action against the disease much more quickly than the rest of the world after being infected.)
* '''Madagascar''' ([[MemeticMutation Closes its only port if someone coughs in Brazil]]; getting Madagascar will be your Flash gaming career's CrowningMomentOfAwesome.) [[invoked]]
** And if it's not Madagascar, it'll be friggin' Australia, Argentina, Japan, and/or New Zealand. This game just doesn't want you to win.

[[https://itunes.apple.com/us/app/pandemic-2.5/id483737492?mt=8 Pandemic 2.5]], a semi-sequel to Pandemic 2 for iOS users, was released on the App Store summer of 2012.

Come try out [[http://www.freeflashgamearcade.com/games/3369/pandemic-1.html the original]] or [[http://www.crazymonkeygames.com/Pandemic-2.html the sequel]] here!

This game has a SpiritualSuccessor in the form of ''Videogame/PlagueInc'', a game released on mobile devices and developed by a company named Ndemic Creations. This successor has an UpdatedRerelease, ''Plague Inc: Evolved'', released for PC, Mac and Linux.

Funny note; there's also a [[http://en.wikipedia.org/wiki/Pandemic_%28board_game%29 cooperative board game]] of [[NamesTheSame the same name]] where the players goal is to CURE the world of a disease epidemic. It also has a reputation for being fairly challenging. [[{{Irony}} Interesting]], [[HilariousInHindsight eh]]?
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!!Pandemic provides examples of:

* AscendedMeme:
** One of the achievements for the Kongregate version of ''Pandemic 2'' is called "President Madagascar Assassination Badge". You have to kill everyone on the realistic (read: hard) setting in 100 days.
** Pandemic 2.5 has three difficulty levels: Casual, Normal, and [[MemeticMutation Madagascar]].
* ApocalypseHow: Planetary Human Extinction is your goal. You can still get Regional and Continental Extinctions (which would effectively mean Global Collapse or Disruption, at the very least) if Humans successfully fight back. Even if you're very unlucky, the spread of your virus is ''guaranteed'' to cause Regional Disruption with all the closures and emergency measures.
* ApocalypticLog: The news reports, as they track infections and lockdowns across the globe.
* ArtisticLicenseBiology: One of the classes you can pick for your disease to be is "parasite". By definition, parasites are not supposed to kill their hosts, merely to live off of them. In real life, if their hosts die, they die as well (unless it's one of those parasites whose life cycle involves multiple hosts). The creator may have mixed up Parasites and [[http://en.wikipedia.org/wiki/Parasitoid Parasitoids]] which actually DO kill the host eventually.
* ArtisticLicenseGeography: For some unknown reason, news reports will occasionally inform you of 'a series of hurricanes' repeatedly slamming places like Brazil and Russia. One hurricane is rare enough in these regions (due to the proximity to the Equator and the freezing climate, respectively), let alone a series of them.
* BookEnds: At the beginning of the game, nations will report about mundane things, like the weather. If everything goes right, your newsfeed then fills up with nations locking down their borders, establishing martial law, and burning bodies to prevent infection. Once the world is entirely infected, the news goes back to weather reports.
%%* ButWhatAboutTheAstronauts
* ColorCodedForYourConvenience: Countries will go from green to yellow-ochre to orange and finally red as the infection intensifies.
* {{Determinator}}: Greenland's hospital. No matter what happens to the rest of the world, Greenland's hospital won't shut down until the [[DefiantToTheEnd very last person in the country dies]], [[AbandonedHospital and sometimes not even then]]. [[MomentofAwesome It's quite impressive]] if you ignore the FridgeLogic. If Greenland's hospital actually closes before the last person in the country dies, you know the world is screwed.
* FlyingDutchman: The one or two ships which sail around the world, looking for a non-existent open port.
* GameplayAndStorySegregation: a disease which has ''no negative effects whatsoever'' will cause a country to start closing ports and burning bodies that haven't died yet. Also, an uninfected country can close its borders and successfully keep a water-, air- or insect-vectored disease out.
* HelloInsertNameHere: You get to name your disease.
** Cue people killing the world with "Death By Chocolate," or infecting the entire world with "pedophilia". Or even causing a disease called "Tea Partyism" that begins in the United States, or "Communism" that starts in Russia.
** Anything from other works: [[Franchise/ResidentEvil The T-Virus]], [[WesternAnimation/{{Futurama}} Boneitis]], [[Franchise/{{Star Trek}} Pon Farr]], [[FinalFantasyVIIAdventChildren Geostigma]]. [[{{Ever17}} Tief Blau]] Or what about [[MyLittlePonyandFriends the Smooze]], or [[VideoGame/ResidentEvil5 Uroboros]]? If you get Madagascar, you might get [[MemeticMutation COMPLETE GLOBAL SATURATION]]....
** Other amusing terrors like [[EnfantTerrible Toddlers]], [[BiggusDickus Giant]] [[GagPenis Green Penis Disease]], and [[TooDumbToLive Stupidity]], the last of which actually killed everyone in the world. Yes, even Madagascar.
--> Mankind was brought to extinction by a severe case of Disco Fever.
** Try going for irony and naming your disease "Living".
-->Victory! Living has successfully eradicated all life on Earth.
** "Tumblr" has caused the destruction of humanity.
** For the lulz, you could name your disease after a supervillain.
--> Dr Doom has wiped out all life on Earth.
** Name it after something that humans would normally need to live. For example, "Dihydrogen Monoxide." [[spoiler: Also known as water.]]
* HollywoodEvolution: Every copy of your disease has the same traits. You can spread your harmless little parasites throughout most of the world, and then give every single one the ability to cause heart attacks simultaneously.
* HonorBeforeReason: As mentioned above, Greenland won't shut down its hospital until everyone dies, but also won't shut down schools, public transport, or its ports. It even [[TooDumbToLive refuses to take government measures]] (i.e. martial law, handing out water and masks, exterminating rodents and insects). If you invest points in drug resistance, Greenland is likely the first to completely die off.
* KillEmAll: The object of the game.
* LuckBasedMission:
** Pretty much the whole thing. If you start in Madagascar, you're halfway there so long as you get off the island before someone coughs.
** Also, the chance of getting a random trait at the beginning of the game. If you start in a certain country with a hot or cold climate, for example, you gain an automatic resistance to hot or cold conditions. However, there are loads of other traits that crop up much less often at the beginning - these include "Catching" (free rodent/insect/waterborne/airborne transmission), "Mutator" (vaccines are slower to engineer than normal), "Isolated" (reduces infectivity), "Famous" (increases visibility, which is bad) and "Expected" (vaccines are faster to engineer than normal). Having any of these less common traits will either make your game ''much'' easier, or otherwise pretty much force you to start again.
%%* AMillionIsAStatistic
%%* NewsTravelsFast
* NintendoHard
** Note that part of the reason for this is simply that the game arguably tricks you. For instance, you shouldn't choose any form of transmission until ''after'' you have infected every region on the planet, because you don't need it to spread your disease and its the ability of the disease to spread through animals, water or the air that makes countries like nation so paranoid. Likewise, you should sell off any symptoms you have at the start. The key to victory is low visibility; again, buy your lethal symptoms only ''after'' you have infected the whole planet. The only thing you should buy is resistance, esp. drug resistance, and you'll need the latter to actually start killing people.
** Even with resistance, you should avoid anything above level II (if even that). Like transmission, the rest of the world will freak out when faced with a disease that cannot be harmed and transmits freely (which has a stone-cold logic, since they are ProperlyParanoid to think that it might mutate and turn lethal at any moment). Of course, its possible to do all this and ''still'' lose the game.
** Several guides will advise you that if you don't start off in Madagascar, you might be better off just restarting the game, over and over until you do. Even then, starting in Madagascar has its problems- it takes much longer to infect the world from Madagascar than from elsewhere (for one of the same reasons its hard to infect it to begin with- one rarely used port); and nations like Cuba can be just as annoying to get at.
* NoCampaignForTheWicked: Averted from the disease's point of view, anyway. [[http://www.kongregate.com/games/DarkRealmStudios/pandemic-american-swine Pandemic: American Swine]] lets you play as the US government, trying to control a swine flu outbreak.
%%* ThePlague
* ProperlyParanoid:
** Madagascar and China.
** Also, the rest of the world when your disease is highly infectious but has no symptoms. It may seem like a massive overreaction to a little, harmless bug, but when it will actually mutate and kill everyone at some point...
--->Mister President! A ''[virus/bacterium/parasite]'' that doesn't do anything has been discovered in ''[city/country]''!
--->'''''Shut. Down. Everything.'''''
** Interestingly, this response has a valid scientific reasoning in real life. If you find a virus that spreads really easily (eg. is endemic) and then mutates to something [[OhCrap lethal]]... It was the main reason for the response to Swine Flu.
%%* RiskStyleMap
* ShoutOut: The TV show ''Series/{{Fringe}}'' had what seemed to be a ShoutOut to this game. A simulated projection of a highly infectious disease is shown to encompass the whole world... except Madagascar.
* SpreadingDisasterMapGraphic: You see a map of the world, with the areas the deadly disease killing off all of humanity has affected. Madagascar will usually not be among them no matter how hard you try.
* StealthBasedMission: The less visible your disease is, the better.
* ThereIsNoKillLikeOverkill: As stated above, a nonlethal disease with limited symptoms will cause the world to go berserk; martial law, burning bodies, closing ports, and the like.
* TrialAndErrorGameplay: Finding the ''just right'' combination of symptoms and resistances can come down to this, especially for new players.
* {{Understatement}}: The winning message for ''Pandemic 2'', only occurring if all 6.3 billion people are dead, begins with the sentence "Mankind's numbers have declined".
* UnusuallyUninterestingSight: Averted. Having "vomiting" or any other extremely noticeable symptom will have everyone freak out.
* UnwinnableByMistake: There's an odd glitch in the first game that lets you get your Infection Rating down to zero. Running the simulation will give you negative points, and your virus will go extinct.
* VideoGameCrueltyPotential: The number of horrible symptoms and sinister ways to spread the disease can cause one to feel like a {{supervillain}}ous OmnicidalManiac as you rain death down upon the world.
* VideoGameCrueltyPunishment: On the other hand, making your disease horribly over the top and gruesome is a sure way to screw yourself over. It would seem that if you are going to be horribly cruel with your disease, the game would prefer that you employ PragmaticVillainy rather than StupidEvil.
* VideoGameGeography: The Earth is actually flat in ''Pandemic'', or at least the transportation methods act as such. For example, a plane travelling from the US West Coast to Australia will never cross the Pacific. It will cross the Atlantic and the Indian Oceans.
* VillainProtagonist: Naturally. This is also an option in ''Pandemic: American Swine'', especially when playing on closed transparency, where one can do any of the following to prevent the spread of swine flu [[ForTheEvulz (or because you want to)]]: intentionally release information to scare the public, covertly murder infected individuals, and [[NukeEm drop nuclear weapons on major US cities to kill the infected in them.]]
* ZombieApocalypse: Combine the right symptoms (necrosis, hemoraging, and insanity) and you get this.
%%** TechnicallyLivingZombie

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Remember, in real life, moving to Madagascar will not make you immune to deadly pathogens.