''Nightshade'' may refer to these games:
* ''VideoGame/Nightshade1992'': A 1992 action-adventure game on the Nintendo Entertainment System.
* ''VideoGame/Nightshade2003'': A 2003 hack and slash on the [=PlayStation=] 2. Part of the ''Shinobi'' series.
* ''VisualNovel/Nightshade2016'': A 2016 visual novel.

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