--> ''"There's a worm in the {{Big Apple|sauce}}. Radioactive green [[AppliedPhlebotinum GLOPP]] has flooded the city's water supply, turning every sewer dwelling creature it touches into a man hunting mutant. This was no accident -- it's the work of Morphix, [[MadScientist a brilliant mastermind gone mad]]. But when things go bad in the city that never sleeps, there's one man who can be counted on to take out the trash: [[TitleDrop Duke]] [[BadAss Nukem]]. Hail to the king, baby!"''
--> '''Game's intro'''

--> ''"Babes, bullets, bombs... damn, I love this job!"''
--> '''-- Duke.'''

'''Duke Nukem: Manhattan Project''' is the fourth entry in the ''VideoGame/DukeNukem'' franchise. It's a sidescrolling platformer, somewhat in style of the first two ''Duke Nukem'' games, developed by Sunstorm Interactive and published by ARUSH Entertainment in 2002.

The game is set after the events of ''VideoGame/{{Duke Nukem 3D}}''. This time, Duke faces another MadScientist, Mech Morphix, and his army of mutants and robots. Morphix wants to use a [[AppliedPhlebotinum radioactive]] [[HollywoodAcid slime]] called [[FunWithAcronyms G.L.O.P.P.]] to mutate insects and other species into giant monstrousness.

''Manhattan'' contains the same side-scrolling gameplay of the first two games, but with the environment itself constructed in 3D, producing an interesting 2.5D hybrid of the earlier games, plus Duke's attitude and mannerisms from ''VideoGame/{{Duke Nukem 3D}}''.

A port of this game was released for XboxLiveArcade in 2010, made directly by 3DRealms.
!This game shows examples of:
* AddedAlliterativeAppeal: The episode titles: Rooftop Rebellion, Chinatown Chiller, Metro Madness, Unholy Underworld, Fearsome Factory, Tanker Trouble, Deviant Drilling and Orbital Oblivion.
* BadAss: Duke has his share of quips here:
** Killing a giant mutant roach in the subway:
--> ''"Mimic '''that'''!"''
** Before the first boss battle (against Morphix in a helicopter)
--> ''"There're only two ways this can end. And in both of 'em, you die!"''
* BagOfSpilling
* BigApplesauce:
-->''"New York... If I can kill them here, I can kill them anywhere!"''
-->''"Time to de-worm the Big Apple!"''
* BreakingTheFourthWall:
** After freeing a babe strapped to a mutant bomb:
--> ''"You must be 18 or older to ride."''
** A lampshade by Duke, after freeing a babe:
--> ''"This is why they have games named after me."''
* TheCoconutEffect: In the (initially mostly dark) Fearsome Factory level, when the lights switch on, they do so with a loud "THUNK".
* DoubleJump: A key gameplay mechanic.
* DualWielding: The gator grunts.
* EvilIsNotWellLit: The G.L.O.P.P. factory levels.
--> ''"Jeez, you'd think Morphix could afford a few light bulbs."''
* ExplodingBarrels
* {{Expy}}: Mech Morphix was originally supposed to be Dr. Proton, the villain of the first Duke Nukem game (as well as the original iteration of VideoGame/DukeNukemForever), but was changed to be an entirely different character during development. The two characters look virtually identical.
* {{Fembot}}: The Femmechs, obviously.
* FrictionlessIce: Featured on "Tanker Trouble".
--> ''"I don't remember buying tickets for [[Disney/DisneyOnIce Mutants On Ice]]"''
* FunWithAcronyms: [[AppliedPhlebotinum G.L.O.P.P.]] stands for ''Gluon Liquid Omega-Phased Plasma''.
* GameEngine: ''[=Prism3D=]''.
* GuideDangIt: There's a secret boss battle, accessible during the last part of the last mission, but only with requirements such as [[GottaCatchEmAll collecting every Nuke]] in every difficulty level, then collecting them all in Hard difficulty and going to a specific place in the last part of the last level.
* HighAltitudeBattle: Several of the levels.
* InconvenientlyPlacedConveyorBelt
* InexplicableTreasureChests: The game puts ammo and health in ordinary-looking crates and barrels.
* InnocentBystander: Hostages.
* KingMook: Except for the helicopter in episode 1, the giant Queen Roach in the middle of the game, and the final boss, all the game's level bosses are simply more powerful versions of standard enemies.
* LevelEditor
* LockAndKeyPuzzle: Lampshaded somewhat: Duke will even openly complain about looking for keys on various occasions.
* LudicrousGibs: The game has its own fair share. Pull off the right kind of kick and you can gib the organic enemies in the game without anything explosive. Quite a few of Duke's deaths also qualify.
* MadScientist: Morphix.
* MadeOfExplodium: Morphix's robots will blow up if hit with anything that would normally gib a mutant, including the aforementioned kick.
* NiceHat: The gator grunts.
* NonMammalianMammaries: The Cockroach Queen.
* NoOSHACompliance: The "Fearsome Factory" episode. Lampshaded by Duke:
--> ''"Seems like Morphix puts worker safety first... right after everything else."''
--> ''"Something tells me this won't pass any safety inspections."''
* OneHitKill: It's possible to terminate the Pig Cops by {{Goomba Stomp}}ing them.
* RefugeInAudacity
* [[spoiler:RescueSex]]: As the ending says:
--> ''"[[spoiler:The Big Apple and the world is saved. Mech Morphix space station will splashdown somewhere in the South Pacific.\\
What's Duke to do? Well, let's just say that all those babes he saved from the bombs are ready to show Duke just how much they appreaciate him. [[TitleDrop Manhattan Project]] has just begun...]]"''
* ScoreScreen: A similar stats screen to Duke 3D.
* {{Shareware}}: The first episode was available as a free download.
* ShoutOut: Check [[ShoutOut/DukeNukem the page]].
* SlipknotPonytail: The Fem-Mechs, except the Level 3 ones.
* SquareCubeLaw: Most notably the Cockroach Queen at the end of Stage 4, but most of the mutants, especially those from smaller creatures such as ratoids and roachoids.
* SuperDrowningSkills: Unlike it's predecessors, it's played straight here. Water won't hurt you, unless you're trying to swim.
* TakeThat: The intro to Deviant Drilling:
--> ''"Morphix and his GLOPP reign are going down faster than [[MegaCorp Enron]]."''
* TakingYouWithMe: The Gator Grunt Boss will blow himself.
--> ''"The fortune cookie didn't say anything about this! You will never take me alive! If this doesn't kill you, the bombs in the subway will!"''
* TemptingFate: After fighting the Queen Cockroach, the underground base starts to collapse, and a boulder falls on her. Then, Duke takes a train and escapes from her...
--> ''"Ah, just in time."''
** ...only for her to reappear again. Cue the BossBattle:
--> ''"Maybe I spoke too soon."''
* TimedMission: The fourth boss fight against the Queen Cockroach is this and a TraintopBattle. Also the sixth boss battle, against a Flyoid Boss.
* UndergroundLevel: Metro Madness, Unholy Underworld (both taking place in a subway station) and Fearsome Factory. (Taking place in a mine factory)
* WhipItGood: The Fem-Mechs.
--> '''''"I am the king of the world, baby."'''''