The GCSE, standing for General Certificate of Secondary Education, is an academic qualification in a specific subject. It is gained at British schools in years 10 and 11 (ages 14-16). As of 2013, children must stay in education until the age of 17, though education includes joining the armed forces between 16 and 18.
[=GCSEs=] replaced the O-levels in 1988, with the idea being an integration of "The National Curriculum". Essentially, every child is taught the same things at roughly the same time. It gets more complicated, however, since there are half a dozen different examining boards each with their own set of [=GCSEs=] -- a Science certificate from the AQA may require slightly different work than an Edexcel one, leading to some people selecting courses based on the perceived ease of exams and/or coursework. One does not have to follow one board across all subjects; doing an Edexcel ICT (Information Communication Technology, i.e. computers) course and an AQA Music course, for example, is quite common.
The grading of the exams used to be A through G and then U. Nowadays there is an A* (said literally, as [[IncrediblyLamePun A-star]]) in front of the A for the best results. The U means "Ungraded", and if you receive a U then that result would be omitted from your final results. A* through C grades are generally regarded as passes. The only compulsory [=GCSEs=] are a minimum of a C in English and Maths, although it will be very difficult to continue studying or find employment if one has no qualifications besides these.
The choice of coursework and exam follows two distinct levels (where such a choice is available). These are "Higher" and "Foundation" Tiers (previously called "Advanced" and "Standard"). If you take a Higher/Advanced course, your possible grades will be A*-D or a U. You cannot attain an E, F, or G grade in the advanced tier. If you take the Foundation/Standard course, your possible grades will be C-G or a U. If you do the standard level course perfectly, your highest award will be a C grade. Which paper a student will do is generally decided between them and their teacher, though depending on the school all pupils in higher-ability classes may do the Higher course.
To continue onto most Sixth Form Colleges, and for all Universities and skilled work, the minimum GCSE requirement is to have achieved the English Baccalaureate. This is 5 [=GCSEs=] at A* to C grade in English, Maths, and at least one other science and humanity.
Back in the '90s, people would joke that you would get some sort of pass grade if you could correctly write your name on the paper. However, in 2012 a number of schools began looking at legal action because of accusations of unfair marking (the grade boundaries were altered). Several [=MPs=] have called for the GCSE to be scrapped, but then that has been happening with regularity since 1988.