* CelebrityVoiceActor: Creator/CandiceBergen as SAL 9000; [[SubvertedTrope subverted]] as she was credited under a pseudonym, "Olga Mallsnerd".
* FakeNationality: Messed around with. Dr. Chandra is supposed to be Dr. Sivasubramanian Chandrasegarampillai, originally from [[BollywoodNerd Madras]], but a naturalized US citizen at the University of Illinois Urbana-Champaign. When they cast the Russian-Jewish American Bob Balaban in the role, they dropped any reference to his Indian heritage (and changed his affiliation to the University of Chicago, to boot).
** Surprisingly more-or-less averted with the rest of the cast. With the glaring exception of Dana Elcar as Dimitri, most of the Soviets are in fact from the Soviet Union (if not Russia specifically), and any others are Czech. Tanya is a special case: she was played by Creator/HelenMirren, who while English is ethnically Russian (her grandfather was an emigre from the RedOctober) and can do a flawless Russian accent.
* FakeRussian: Dana Elcar as Moiseievich has the most [[OohMeAccentsSlipping trouble with his accent]]; his Russian radio messages are dubbed. Creator/HelenMirren's grandfather was Russian (their family was originally named Mironov) and she can pull off the accent, even though she isn't fluent in the language. The rest of the actors playing the ''Leonov'' crew are variously really Russian, from other Soviet republics, or Czech.
* FreezeFrameBonus: In the very first interior shot of the ''Leonov'', the camera tilts down from a closeup of a computer monitor in the medical bay. Printed underneath the monitor is a paragraph of English text, beginning with "You may leave the lavatory if the green exit light is on over the door...." This is actually step 4 of the Zero Gravity Toilet instructions from ''2001''. Not only do you have to freeze-frame it, you need to watch the movie on Blu-Ray in order to make out the text! Additionally, the image on the monitor is captioned "KIRBUK" in Cyrillic (see MildlyMilitary on the Main page.)
* HeyItsThatVoice: Creator/CandiceBergen portrays HAL's earthbound twin, [[DistaffCounterpart SAL 9000]]. Her fisheye lens is blue - a bit of RedOniBlueOni, [[WildMassGuessing perhaps]]?
* LifeImitatesArt: Around the year 2010, scientists began noticing the color of Jupiter's atmosphere is changing, just not as fast as it happens in the film.
* TheOtherDarrin: Roy Scheider as Heywood Floyd, replacing William Sylvester from ''2001''. (A still of Sylvester as Floyd, touching the monolith on the Moon, can be seen in the recap sequence in the beginning.) Averted by Keir Dullea and Douglas Rain, who reprise their roles as Bowman and HAL.
* PropRecycling: The blue ''[[TwoThousandOneASpaceOdyssey 2001]]''-style spacesuit hanging in the ''Discovery'' pod bay ended up in the hands of the crew of ''Series/BabylonFive'' years later. (This is precisely the kind of thing that Creator/StanleyKubrick wanted to avoid by destroying all of ''2001'''s sets and props.) They did their best to change what they could on it, "[[Creator/JMichaelStraczynski though it was pretty much what it was regardless.]]" To make it further HilariousInHindsight, the episodes the suit appeared in both involved time travel, a lost astronaut appearing and disappearing, and a mild degree of MindScrew.
** The space pod that appears in Watto's junkyard in ''StarWars Episode I: ThePhantomMenace'' may also have come from ''2010'''s ''Discovery'' pod bay, but this has not been confirmed.
* ScienceMarchesOn: This was Clarke's motivation to keep writing sequels to ''2001''. The plot of ''2010'' was inspired by the Voyager probes' flybys of Jupiter, especially the possibility of life under Europa's icy crust, and he wrote ''2061'' in response to the 1986 observations of Halley's Comet.
** This made Stanley Kubrick's version of the plot, moving the mission in ''2001'' from Saturn to Jupiter, very fortuitous. The first novel sent ''Discovery'' to Saturn, with the Monolith found in the vicinity of Iapetus (spelled "Japetus" in the novel, a common British spelling for the moon). The most interesting feature on Iapetus is a ridge that gives it a walnut-like shape. The real-life idea that Europa is now considered more likely to harbor life than Mars makes this change downright fateful!
** After Clarke died, the Cassini probe showed that it would now be possible to do a story about a monolith on Iapetus protecting emerging life on Enceladus, since it has even better evidence of liquid water under its crust than Europa does.
* ShoutOut: The prop designers for ''Series/BabylonFive'' used the design of the ''Leonov'' as inspiration for the Omega Destroyers used by the Earthers on that show. Compare the rotating gravity sections of the two ships, they have a largely identical profile. The designer of the digital prop on B5 assumed that someone would catch his obvious joke and have him fix it, but nobody noticed.
* WhatCouldHaveBeen: Arthur C. Clarke suggested that Peter Hyams try to get Ben Kingsley, who had just won his Oscar for ''Film/{{Gandhi}}'', to play Chandra. Twenty years later, Hyams would direct Kingsley in ''Film/ASoundOfThunder''.
** What's odd is that the film version of ''2001'' gave HAL's creator's name as "Mr Langley", rather than "Dr Chandra". You have to wonder why they didn't simply rename the character Langley when they cast a white guy...
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