* ActorAllusion: Niall, played by Rutger Hauer, is introduced [[Film/TheHitcher picking up a hitchhiking Jason]].
* {{Defictionalization}}: Of a sort - you can buy [=TruBlood=] in the real world, but it's a blood ''orange'' flavour drink, not synthetic blood.
* FakeAmerican: The actors who play Sookie (Creator/AnnaPaquin, from New Zealand via Canada), Jason (Ryan Kwanten, from Australia), Bill (Stephen Moyer, from England), as well as some recurring characters such as the magister (Željko Ivanek, from Yugoslavia) and Marnie (Fiona Shaw, from Ireland).
* TheOtherDarrin:
** Carolina Bellefleur was recast between her appearances in seasons 4 and 6. Incidentally, this came with a marked change in personality from an elegant and good-natured GrandeDame to an overbearing, senile, RacistGrandma.
** James was recast with Nathan Parsons in the final season due to previous actor Luke Grimes not wanting to do a gay romance storyline.
* TheOtherMarty: Tara was originally going to be played by Brook Kerr; her scenes in the pilot were reshot with replacement Rutina Wesley.
* TheNthDoctor: Claude's change of actors (Neil Hopkins to Giles Matthey) was explained by faeries being able to change their appearance at will. Also a bit of a TakeThat to Hopkins since Sookie commented that new!Claude's old look was unattractive and had "meth teeth."
* RomanceOnTheSet: Creator/AnnaPaquin and Stephen Moyer are married in real life.
* WhatCouldHaveBeen: According to the Ultimate Fan Experience Q&A shown before the third season premiere, Alexander Skarsgård had originally auditioned for the role of Bill, not Eric. Imagine ''that''.
** Katee Sackhoff was approached for the role of Debbie Pelt. Sadly, she turned it down.
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