* ActorAllusion: William Conrad is named after the character from the radio show Gunsmoke. He also bares a striking resemblance to Patrick Stewart.
* FanNickname: Leggie or Leggah for Legato; Bashu (i.e. the Japanese pronunciation) for Vash; Wolfie, Wolf or Nick for Nicholas D. Wolfwood; sometimes Naibuzu (the Japanese pronunciation) for Knives.
* HeyItsThatVoice: To name a few; Creator/JohnnyYongBosch (in his first anime role!) and Creator/MasayaOnosaka as Vash, Creator/JeffNimoy and Creator/ShowHayami as Wolfwood, [[Creator/DorothyEliasFahn Dorothy Fahn]] and Creator/HiromiTsuru as Meryl, Creator/LiaSargent and Creator/SatsukiYukino as Milly.
** In Creator/{{Funimation}}'s dub of the movie, Meryl is [[TheOtherDarrin Darrin'd]] by Creator/LuciChristian, best known as Nami from ''Franchise/OnePiece'' (though she has ''many'' other roles to her name)
** John Snyder playing a CorruptCorporateExecutive?! Preposterous! [[Manga/OutlawStar Wait...]][[note]] Snyder played Cliff Schezar in Episode 2 of ''Trigun'', and also played Ronald [=MacDougall=] in ''Outlaw Star''.[[/note]]
** Creator/MonaMarshall, who voices Kite from the [[Franchise/{{dothack}} .hack quadrilogy]] (as well as ''WesternAnimation/SouthPark'''s Sheila Broflovski) voices... Kaite, a 2-part character from ''Trigun''.
** Young Knives is voiced by Creator/JoshuaSeth, voice of Tai from ''Anime/DigimonAdventure''. It's very easy to tell, seeing as how he does nothing to differentiate Young Knives from his Tai voice. One could put a voice clip of Young Knives onto Tai and Digimon fans who haven't seen Trigun would be confused.
** Rem is voiced by veteran voice actors on both sides of the Pacific.
*** In English, she's voiced by Creator/BridgetHoffman, voice of Namie from ''Manga/{{Durarara}}''. Now, try to imagine her suddenly as a mother figure to [[Creator/JohnnyYongBosch Izaya]]. For what it's worth, Hoffman also played Belldandy in the ''Manga/AhMyGoddess'' movie (and has dubbed at least three other roles originated by Creator/KikukoInoue).
*** In Japanese, Rem is voiced by Creator/AyaHisakawa, best known as Ami/Mercury from ''Anime/SailorMoon''. For what it's worth, Hisakawa also plays Skuld in the ''Anime/AhMyGoddess'' franchise.
** Can't forget that Legato shares an English VA with ''[[Manga/RurouniKenshin Kenshin]]'' of all people!
* PortmanteauSeriesNickname: "[=TriMax=]" for ''Trigun Maximum''.
* TheOtherDarrin: The only voice actor to return to reprise their role for the movie's English dub is Creator/JohnnyYongBosch as Vash. Creator/JeffNimoy and [[Creator/DorothyEliasFahn Dorothy Fahn]] were both interested in reprising their roles of Wolfwood and Meryl respectively, but Creator/{{Funimation}} replaced them behind their backs mid-negotiations. Lia Sargent was also replaced as Milly, but this was expected as she had retired years earlier.
* WhatCouldHaveBeen: Much like ''Manga/InuYasha'', ''Trigun'' was one of the Creator/AdultSwim anime shows that was meant for Creator/CartoonNetwork's Creator/{{Toonami}} block, but ended up airing on [adult swim] instead due to content issues (in this case, it was due to the amount of gun violence that would have to have been edited down... and a few scenes got censored on [as] anyway)[[note]] The most notable cut made in the Adult Swim airing was in Episode 7, where Brilliant Dynamites Neon shoves his gun in Kaite's mouth and keeps it there for nearly 30 seconds.[[/note]]
** Oddly enough, ''Trigun'', along with the original 1963 ''Anime/AstroBoy'', was showcased during the April Fools Day 2012 Toonami broadcast, despite the two not having aired on Toonami before.
** Ever since Toonami was revived on [adult swim] hours, ''Trigun'' now has a chance to make an official premiere on Toonami (again, much like ''Manga/InuYasha'' before it). So far, however, it has yet to do so. Though considering ''Badlands Rumble'' was picked for their December movie marathon...
* WordOfGod: Nightow says that Kuroneko-sama is female and that Vash and Wolfwood aren't in a gay relationship, yaoi {{Doujinshi}} notwithstanding. He has also provided Wolfwood with about half a dozen middle names to go with that 'D.'
** The best obviously being Dokonokuminomonjawaresumakinishiteshizumetarokakora.
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