* ActorAllusion: William Conrad is named after the character from the radio show Gunsmoke. He also bares a striking resemblance to Patrick Stewart.
* FanNickname: Leggie or Leggah for Legato; Bashu (i.e. the Japanese pronunciation) for Vash; Wolfie, Wolf or Nick for Nicholas D. Wolfwood; sometimes Naibuzu (the Japanese pronunciation) for Knives.
* PortmanteauSeriesNickname: "[=TriMax=]" for ''Trigun Maximum''.
* TheOtherDarrin: The only voice actor to return to reprise their role for the movie's English dub is Creator/JohnnyYongBosch as Vash. Creator/JeffNimoy and [[Creator/DorothyEliasFahn Dorothy Fahn]] were both interested in reprising their roles of Wolfwood and Meryl respectively, but Creator/{{Funimation}} replaced them behind their backs mid-negotiations. Lia Sargent was also replaced as Milly, but this was expected as she had retired years earlier.
* WhatCouldHaveBeen: Much like ''Manga/InuYasha'', ''Trigun'' was one of the Creator/AdultSwim anime shows that was meant for Creator/CartoonNetwork's Creator/{{Toonami}} block, but ended up airing on [adult swim] instead due to content issues (in this case, it was due to the amount of gun violence that would have to have been edited down... and a few scenes got censored on [as] anyway)[[note]] The most notable cut made in the Adult Swim airing was in Episode 7, where Brilliant Dynamites Neon shoves his gun in Kaite's mouth and keeps it there for nearly 30 seconds.[[/note]]
** Oddly enough, ''Trigun'', along with the original 1963 ''Anime/AstroBoy'', was showcased during the April Fools Day 2012 Toonami broadcast, despite the two not having aired on Toonami before.
** Ever since Toonami was revived on [adult swim] hours, ''Trigun'' now has a chance to make an official premiere on Toonami (again, much like ''Manga/InuYasha'' before it). So far, however, it has yet to do so. Though considering ''Badlands Rumble'' was picked for their December movie marathon...
* WordOfGod: Nightow says that Kuroneko-sama is female. He has also provided Wolfwood with about half a dozen middle names to go with that 'D.'
** The best obviously being Dokonokuminomonjawaresumakinishiteshizumetarokakora, meaning "daily cigarette intake."
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