* ActorAllusion:
** In "Victor the Happy Ghost," Peter refers to ''Series/TheBobNewhartShow'' as his favorite TV show. Lorenzo Music co-created the series.
** In "Jailbusters," the ghostly judge is voiced by [[Series/TheFreshPrinceOfBelAir James Avery]].
** The episode "Ghostbuster of the Year" (an episode long ''Film/CitizenKane'' reference) seems to have been produced solely to showcase Creator/MauriceLaMarche's impersonation of Creator/OrsonWelles.
** In "A Fright at the Opera", before the Diva selects Peter as her bodyguard, she states "I hate Mondays". Lorenzo Music's (Peter's voice actor) most famous role, Garfield, also has a distaste for that particular day.
* ExecutiveMeddling: Despite its runaway success, Creator/{{ABC}} and the focus group Q5 decided they needed to "fix" the show. And not just once. Janine was changed to be more feminine and meek, and received round glasses because her pointy ones could scare children. More changes were forced upon the writing staff starting with Season 3. Recurring child characters were added. More focus was placed on Slimer, who spun off into his own (doomed) cartoon in Season 4. The whole team ended up taking on fixed roles: Egon was "The Brain", Ray was "The Hands", Peter was "The Mouth" and Winston was "[[UnfortunateImplications The Driver]]". This was enough to make Creator/JMichaelStraczynski, the head writer at the time, leave his position after Season 3 (though he wrote some later scripts for the show as a free-lance writer).
** The only reason the Egon/Janine relationship was never allowed to go anywhere? Harold Ramis hated the idea, and since the actors had creative control over their characters, it was vetoed. This is why it was totally dropped in ''Film/{{Ghostbusters}} 2'' for a Janine/Louis relationship.
** Q5 had also wanted Straczynski and the other writers to ditch Ray, as they felt he was a pointless character. However, this was one change that was quickly and successfully vetoed.
* HeyItsThatVoice: (Quoth [[http://www.x-entertainment.com/messages/653.html X-Entertainment]]: "If you're new to the show, it'll take awhile for you to stop expecting [[{{Garfield}} lasagna jokes]] [from Peter, who is voiced by Lorenzo Music in the early half of the show's run].")
** It becomes HilariousInHindsight, because in 2004, a live-action Garfield movie would be released. In that film, Garfield is voiced by Creator/BillMurray, who played Peter Venkman in the Ghostbusters movie.
*** Because Bill Murray complained to the producers that his character "sounds like Garfield", they replaced him with [[FullHouse Uncle Joey]] (Dave Coulier).
** Creator/KathSoucie played the post-{{Chickification}} Janine. It was one of her earliest roles.
** The original Janine was voiced by Laura Summer, who would reuse the voice for [[{{DigimonAdventure}} Patamon]].
** Creator/MauriceLaMarche played Egon (and sounds ''exactly'' like The Brain would years later).
*** According to TheOtherWiki, initially they wanted Maurice not to do a Harold Ramis impression, but as an impressionist, Maurice felt he couldn't properly play Egon ''without'' following Ramis' example (he won the part anyway with it). He also tried a "Woody Allen" approach, but it didn't fit Egon's personality.
** Creator/FrankWelker pulled [[TalkingToHimself double-duty]] as Ray and Slimer.
** The ''Slimer!'' shorts featured Creator/CreeSummer as Chilly Cooper, an ice cream truck driver who befriends Slimer.
** Crowley from "The Halloween Door" was voiced by Michael Rye, better known as [[WesternAnimation/AdventuresOfTheGummiBears Duke Igthorn]].
** In "Ghostworld" Mrs. Spengler was voiced by Rose Marie, better known as [[Series/TheDickVanDykeShow Sally Rogers.]] An earlier appearance near the end of an episode had Creator/MauriceLaMarche voice her for the last few seconds when she sent the guys out on a call.
* TheOtherDarrin: After the syndicated episodes, Dave Coulier replaced Lorenzo Music as Peter and Kath Soucie replaced Laura Summer as Janine. A season later, Arsenio Hall left for his talk show and was replaced by Buster Jones.
** In the second season, whenever the Stay Puft Marshmallow Man appeared, Frank Welker handled any vocal effects. In Season 3's "Sticky Business," John Stocker took over the role. Later in Season 5's "Partners in Slime," Welker again voiced the character for a brief cameo.
* PromotedFanboy: A number of people involved at the start of production were fans of the movie. Creator/MauriceLaMarche is one such example.
* TakeThat: Dr. Basingame, a [[ConMan charlatan spiritualist]] first appearing in "The Spirit of Aunt Lois", wore a safari jacket and camera around his neck in that episode - an awful lot like the wardrobe of Jake Kong from ''WesternAnimation/FilmationsGhostbusters''. This was deliberate; WordOfGod said Basingame was a deliberate swipe against the [[DuelingShows rival show]].
* TalkingToHimself: Creator/FrankWelker (Ray, Slimer, sometimes also voices ghosts -- he's a ManOfAThousandVoices) and Creator/MauriceLaMarche (Egon, and the Umpire in "Night Game").
* WhatCouldHaveBeen: Creator/{{Filmation}} was in talks to animate this series. If they had, at the very least, [[WesternAnimation/FilmationsGhostbusters their show]] never would've happened.
** Ernie Hudson (Winston in the movies) auditioned for his own character.
** In light of falling ratings after the Slimer ReTool, producers asked JMS to return as head writer for Season 6. JMS had other projects at the time, though he agreed to write a few episodes (chief among them "Janine, You've Changed").
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