* ActorAllusion: When Femme Fatale challenges the Powerpuff Girls to name some memorable female superheroes, Bubbles mentions Supergirl and Batgirl. Bubbles's voice actor, Tara Strong, voiced Batgirl in [[WesternAnimation/BatmanTheAnimatedSeries The New Batman Adventures]] some time earlier.
* AdoredByTheNetwork: Along with ''WesternAnimation/DextersLaboratory'', was Creator/CartoonNetwork flagship series (during the "CartoonCartoons" era of Cartoon Network) that was rerun daily until 2002.
* AndYouThoughtItWouldFail: The test screening for the first pilot was an absolute disaster, with children complaining about the unusual character designs and one even going as far as to say that Craig [=McCraggen=] should ''be fired''[[note]]This kid would later serve as the inspiration for [[TakeThat the show's bully Mitch Mitchelson]][[/note]]. Craig went to work redesigning the characters with more traditional features, but then-president of Creator/CartoonNetwork Mike Lazo reassured him that a negative reaction was better than a lukewarm reaction, and that they shouldn't change a thing.
* BannedEpisode: The Powerpuff Girls series finale "See Me, Feel Me, Gnomey" was banned, due to the heavy use of strobe effects (which would have triggered epileptic seizures in more sensitive viewers, much like the notorious ''Franchise/{{Pokemon}}'' episode "Electric Soldier Porygon." Reportedly, it was banned for allegedly having Communist undertones, but this was never proven). The episode can now be seen on the complete series DVD set for the show and on the complete series collection on Netflix.
* BoxOfficeBomb: Warner Bros marketing for the movie was quite lousy (as stated in the main page), but CN did their part and promoted it to heck and back (even AdultSwim got involved). Outside the channel, however, there was barely any mention of it. Not helping was it was pitted against ''Film/MenInBlackII'' on the opening weekend, was overshadowed by the surprise hit ''Like Mike'' and Warner Bros focusing their campaign on the ''Film/ScoobyDoo'' live-action movie. As such it preformed poorly. Because of this, the series finales for ''WesternAnimation/EdEddNEddy'' and ''WesternAnimation/CodenameKidsNextDoor'' were scaled back to made-for-TV fare rather than made into feature films.
* CreatorBacklash: [[Creator/LaurenFaust Lauren Faust]] has stated she regrets writing the episode featuring [[StrawFeminist Femme Fatale]] (season two's "Equal Fights") due to receiving death threats from the kind of uninformed, [[DoesNotLikeMen misandrist]] feminists that would agree with Femme Fatale's worldview. Annoyingly, these exact same people then quote her [[QuoteMining out of context]] making it sound like she's decided she was wrong. She also felt as if it was too simplistic a take on such a hot-button issue as feminism.
* {{Defictionalization}}: The PPG [[http://thumbs3.ebaystatic.com/d/l225/m/m5kQnM-yeV3lqIrsVnQY2Mg.jpg waffle iron]] from "Collect Her." Ironically, the writers put that in so the episode because they thought it was too absurd to feel like ProductPlacement for actual PPG stuff.
* DevelopmentGag: The designs of the Run-of-the-Mill Girls from "Oops, I Did It Again" were based on redesigns Craig [=McCracken=] came up with after the early pilot received negative test audience reactions due to the girls' bug-like designs.
* HeyItsThatVoice:
** Blossom is [[WesternAnimation/AnAmericanTail Tanya Mousekewitz]], [[WesternAnimation/KiddVideo Glitter]], and [[WesternAnimation/TeenTitans Chrysalis Eater]].
*** In Russia, she's [[WesternAnimation/StevenUniverse Pearl]].
** [[Creator/ElizabethDaily Buttercup]] is [[WesternAnimation/{{Rugrats}} Tommy Pickles]], [[WesternAnimation/ChalkZone Rudy Tabootie]], and [[WesternAnimation/RoughnecksStarshipTroopersChronicles Isabell "Dizzy" Flores]].
*** In Russia, Buttercup is the 2nd voice of [[WesternAnimation/AdventureTime Cake]].
** [[TaraStrong Bubbles]] is [[WesternAnimation/BatmanTheAnimatedSeries Batgirl]], [[WesternAnimation/TeenTitans Rav]][[VideoGame/InjusticeGodsAmongUs en]], [[VideoGame/FinalFantasyX Rikku]], [[WesternAnimation/TheFairlyOddParents Timmy Turner]], [[WesternAnimation/MyLittlePonyFriendshipIsMagic Twilight Sparkle]], [[VideoGame/LollipopChainsaw Juliet Starling]], [[VideoGame/BatmanArkhamSeries Harley]] [[VideoGame/InjusticeGodsAmongUs Quinn]], and was also in ''Rugrats'' with EGDaily as Tommy's little brother, Dil (first seen in ''The Rugrats Movie'').
** [[Creator/TomKane The Professor]] is SelfDemonstrating/{{Magneto}} and [[StarWarsTheCloneWars Yoda]]. He had also become a judge in the [[WesternAnimation/TheLegendOfKorra Southern Water Tribe]].
** [[TomKenny The Mayor]] is [[WesternAnimation/SpongeBobSquarePants SpongeBob]], [[WesternAnimation/TransformersAnimated Starscream]], [[WesternAnimation/AdventureTime the Ice King]], and [[WesternAnimation/TheBatman The Penguin]].
** [[Creator/JenniferHale Ms. Keane, Princess and Sedusa]] is [[KnightsOfTheOldRepublic Bastila Shan]] and [[Franchise/MassEffect Female Shepard]].
** Mojo Jojo is [[VideoGame/FinalFantasyX Maester Kinoc]], [[VideoGame/ValkyriaChronicles General Gregor]], and [[Franchise/{{Scream}} the Voice Changing Device]]. TelltaleGames fans may also know him as [[VideoGame/SamAndMaxTheDevilsPlayhouse General Skunka'pe]] and [[VideoGame/TalesOfMonkeyIsland Reginald]] [[VideoGame/PokerNightAtTheInventory Von]] [[VideoGame/PokerNight2 Winslow]].
*** And [[VideoGame/SamAndMaxFreelancePolice Abraham Lincoln]].
*** In the Japanese dub, he's [[Anime/GingaDensetsuWeed Hougen.]]
*** [[RuleOfThree In Mexico, Germany, and Taiwan]], he is [[WesternAnimation/MyLittlePonyFriendshipIsMagic Discord]].
** [[GreyDeLisle Femme Fatale]] is [[WesternAnimation/AvatarTheLastAirbender Azula]], [[WesternAnimation/TheGrimAdventuresOfBillyAndMandy Mandy]], [[WesternAnimation/DannyPhantom Sam Manson]], [[WesternAnimation/TuffPuppy Kitty Katswell]], and [[CliffordTheBigRedDog Emily Elizabeth]].
** [[Creator/JimCummings Fuzzy Lumpkins]] is [[WesternAnimation/GoofTroop Pete]], [[ThePrincessAndTheFrog Ray]], and both [[Franchise/WinnieThePooh Pooh and Tigger]] (replacing Sterling Holloway and Paul Winchell respectively).
** [[Creator/JeffBennett Ace, Grubber and Big Billy]] are also WesternAnimation/JohnnyBravo and JustForFun/CandleJack from ''Freakazoid''.
** Mike Believe (from the episode "Imaginary Fiend") is [[VideoGame/TheWorldEndsWithYou Joshua]] and [[VideoGame/DissidiaFinalFantasy Onion Knight]] ([[RetroactiveRecognition not that you'd recognise his voice]]).
** [[Creator/JessHarnell Gnomey]] (from the banned episode "See Me, Feel Me, Gnomey") is [[WesternAnimation/{{Animaniacs}} Wakko]]. They originally wanted Po from ''WesternAnimation/KungFuPanda'' (Jack Black), but they didn't have enough in their budget for a celebrity voice actor.
** [[RobPaulsen Brick and Boomer]] are [[WesternAnimation/{{Animaniacs}} Yakko]].
** [[JuneForay Rocky the Flying Squirrel]], [[WesternAnimation/LooneyTunes Witch Hazel, and Granny]] was Madame Argentina in "I See A Funny Cartoon In Your Future."
** Phyllis Diller was Mask Scara in "A Made Up Story."
** [[MarkHamill Evil Cat]] (from the episode "Cat Man Do") is [[WesternAnimation/BatmanTheAnimatedSeries Joker]], [[WesternAnimation/RegularShow Skips]], and [[TimeSquad The Larry 3000]].
** Fibonacci Sequins ("Dance Pants") was the original [[ThomasTheTankEngine Mr]] [[Music/RingoStarr Conductor]] and the drummer for TheBeatles.
** Mexico and Germany assigned [[WesternAnimation/MyLittlePonyFriendshipIsMagic Discord]] to be Mojo.
** The couple who put a ban on the girls' superheroing are [[WesternAnimation/TheFairlyOddParents Cosmo and Wanda]] (likely also a CastingGag).
** Taiwan & Russia assigned [[WesternAnimation/RegularShow Mordecai]] to be Mojo.
** [[JamesArnoldTaylor Brian]] (from "Documentary") is [[VideoGame/FinalFantasyX Tidus]], [[RatchetAndClank Ratchet]], and [[StarWarsTheCloneWars Obi Wan]]
** [[JohnDiMaggio Captain Crack McGraigen]] is [[WesternAnimation/{{Futurama}} Bender]], [[GearsOfWar MarcusFenix]], [[WesternAnimation/AdventureTime Jake]], [[WesternAnimation/BatmanTheBraveAndTheBold Aquaman]] and [[PoundPuppies2010 Niblet]].
** [[KevinMichaelRichardson The Bogeyman]] is [[WesternAnimation/TheSpectacularSpiderMan L. Thompson Lincoln]], [[Disney/LiloAndStitch Gantu]], and [[WesternAnimation/TransformersPrime Bulkhead]].
** The original voice for Lil' Arturo was [[RockosModernLife Rocko]] and [[Series/{{Reno911}} Deputy Garcia]].
** The Amoeba boys are [[WesternAnimation/GIJoeARealAmericanHero Leatherneck]], [[WesternAnimation/FantasticFour the Thing]], and [[WesternAnimation/DuckTales Burger and Bouncer Beagle]].
* InMemoriam: The episode ''The City of Frownsville'' was dedicated to those who were killed during the infamous World Trade Center of Manhattan, New York, USA collapse on September 11, 2001.
* KeepCirculatingTheTapes: "See Me, Feel Me, Gnomey" has never been shown in the U.S., not even in the current runs on Boomerang. It ''is'' on the complete series DVD set and on Netflix.
* MilestoneCelebration: The 50th issue of the comic book, ''Deja View''.
* NamesTheSame: Mr. Mime shares his name with a significantly happier and far more colorful Pokemon.
* PlayingAgainstType:
** Creator/TomKane as Him.
** Creator/JenniferHale as SpoiledBrat Princess Morebucks.
* RelationshipVoiceActor: The Mexican Spanish dub has two hilarious cases of this:
** Cristina Hernandez (Blossom) and Rossy Aguirre (Buttercup) voiced [[Anime/SaberMarionetteJ Lime and Cherry]] respectively, two girls from another trio of super-powered girls living with a guy, except their personalities are different between the two series.
** Also, Cristina Hernandez, along with Enrique Cervantes (Mojo Jojo) and Sergio Gutierrez Coto (The Narrator) voiced [[Film/TheDarkKnightRises Catwoman, Bane]] and [[Film/TheDarkKnightSaga Batman]] respectively. That's right, The Narrator is the [[Franchise/{{Batman}} The Dark Knight]] and he's fighting against Blossom and Mojo Jojo!
** Imagine [[WesternAnimation/MyLittlePonyFriendshipIsMagic Gilda and Fluttershy fighting Discord]] with Blossom.
* RomanceOnTheSet: Husband and wife [=Craig McCracken=] and Lauren Faust met and fell in love while working on this show as creator/director and storyboard artist, respectively.
* TalkingToHimself:
** TomKenny voices the Mayor, the Narrator, Mitch Mitchelson, and Snake and Lil' Arturo of the Gangrene Gang.
** Creator/JeffBennett voices Ace, Grubber, Big Billy, and Dick Hardly.
** Creator/TomKane voices the Professor and HIM.
** Roger L. Jackson voices Mojo Jojo and Butch of the Rowdyruff Boys.
** Creator/JenniferHale voices Ms. Keane, Princess Morbucks and Sedusa.
** Chuck [=McCann=] voices all three Amoeba Boys.
** RobPaulsen voices both Brick and Boomer.
** KathSoucie supplied the voices for Harold Smith's wife, son, and daughter.
** The three actresses for the girls also voiced one each of the three criminal animals from "Sweet 'N Sour."
* ThrowItIn: A lot of the narrator's closing lines [[https://twitter.com/CrackMcCraigen/status/619252796739600385 were improvised]] by Creator/TomKenny.
* TropeNamer:
** PowerpuffGirlHands
** SoOnceAgainTheDayIsSaved
* WhatCouldHaveBeen:
** Before the Girls, Craig played around with a luchador superhero character as the star for his thesis film, but after drawing a birthday card for his brother with three cute, Margret Keane-inspired girls, he though the idea of those little girls fighting bad guys was hilarious and chose that instead.
** The original tone of the cartoon was meant to be much more adult (it was called "The Whoopass Girls" after all). One can only imagine what that series would've been like if Craig hadn't made it more kid-friendly.
** One planned episode, ''Deja View'', about the girls visiting an alternate universe ruled by their evil versions, ended up being cancelled due to the visuals requiring the budget to go overboard (which they were already stretching). It wound up being given to the comic book writers and turned into [[MilestoneCelebration the 50th issue]].
** As said on the main page, Craig wanted Jack Black to voice the Gnome in "See Me, Feel Me, Gnomey", but they couldn't due to him being too busy and expensive.

!!This show [[ImageSource provides the page image]] for:

* Animated series:
** EasyImpersonation ("Powerpuff Bluff")
** HarmlessVillain ("Geshundfight")
** Monster.CartoonNetwork ("Knock It Off")
** MadeOfGood
** MyBrainIsBig ("Mr. Mojo's Rising")
** PowerpuffGirlHands ("Mime for a Change")
** PrisonRape ("Cootie Gras")
** SissyVillain
** TechnicolorNinjas (fan-art)
* Comicbooks:
** DrivenByEnvy

----