* ActingForTwo: One episode had [[ThisIsSpinalTap Bobbi Flekman]] appearing. Another episode had Fran Drescher acting as herself and as Fran Fine simultaneously.
** In "Not Without My Nanny", Charles plays both Max and the Sultan.
* ActorAllusion: Happened often with guest stars.
-->Fred (played by Donald O'Connor): Let's face it, Fran, I'm just never going to be known for my dancing.
** They also constantly mentioned that Grandma Yetta was played by the same actress who was Millie Halper on ''The Dick Van Dyke Show.''
** During the closing credits of "The Gym Teacher", as Fran and Miss Stone (nee Wickavich) are looking through a yearbook at a picture of Fran's old boyfriend, Miss Wickavich tells Fran "A boy like that, who'd kill your brother. Forget that boy and find another. One of your own kind, stick to your own kind!", which are lyrics from ''Theatre/WestSideStory''. Rita Moreno, who played Miss Wickavich, sang those very lines in the film adaptation.
** In "Stock Tip", as Fran flirts with Glenn, played by Corbin Bernsen:
-->'''Fran:''' (''on what Glenn's job is'') So, we've ruled out Rabbi, and I can tell you're not a lawyer...
-->'''Glenn:''' Why can't I pass as a lawyer?
-->'''Fran:''' Well, not in New York. I mean, [[Series/LALaw maybe in L.A.]]...
** Happened with Fran Drescher herself. In one episode, she plays Bobbi Flekman, a character she'd already played on ThisIsSpinalTap. There are also several references to SaturdayNightFever, in which Fran Drescher played a minor role.
** The show made a couple of references to the movie ''The Hand That Rocks the Cradle.'' Apart from simply sharing the same "nanny" premise, Madeline Zima appeared in both.
* ActorSharedBackground: Almost all of Fran Fine's life (except working at a bridal shop; her mother worked at one) was taken almost verbatim from Fran Drescher's own life. Both are from Queens, both have parents named Morty and Sylvia and a sister named Nadine, both graduated from Hillcrest High (with [[{{EverybodyLovesRaymond}} Ray Barone]]/Ray Romano.)
* TheDanza: Fran Fine is played by Fran Drescher.
* DawsonCasting: Done intentionally for laughs in S3 Ep 12, "The Kibbutz". Fran and Val play teenage versions of themselves in a flashback.
* FakeNationality / FakeBrit: Daniel Davis as Niles, who is from Arkansas. He is good at it though, to the point where Charles Shaughnessy (Maxwell Sheffield), an actual Brit, was told by some critics that he should take lessons from Davis in order to get his "[[RealityIsUnrealistic fake]]" accent right.
** {{Lampshaded}} in a late episode, where Niles has a bit part in Gracie's play and does very badly. Citing a review, he asks Max, "Do you think my accent sounded fake?"
* HeyItsThatGuy: Multiple times, one example being the episode "Kissing Cousins" where Fran's date([[spoiler: who she later finds out is her cousin]]) is Creator/JonStewart.
** [[Film/{{X-Men}} James Marsden]] was Eddie, Maggie's first boyfriend during the first season.
** The boy in ''Film/KindergartenCop'' who told Ahnuld "Boys have a penis. Girls have a vagina." is the bratty son of Maxwell's client Fran has to watch, as mentioned in BadlyBatteredBabysitter.
** [[Series/{{Seinfeld}} Babu Bhatt]] is one of the representatives of the Professional Butler's Association in "The Nanny, the Butler, the Wife and Her Mother".
** [[MySoCalledLife Patty Chase]] was married to Mr. Sheffield
** As was [[Series/{{Seinfeld}} Justin Pitt]].
** In addition, before playing Niles, Daniel Davis played Moriarty on ''Series/StarTrekTheNextGeneration''.
** Danny Imperialli was played by Jonathan Penner, who placed seventh in the Cook Islands season of ''Series/{{Survivor}}''.
* HeyItsThatVoice: In the Latin American dub, the voices of Fran and Maggie are Sailor Mars and Sailor Mercury from ''Anime/SailorMoon'', respectively.
* OldShame: When Maggie researches the Sheffield family history for a school project and casually mentions that the family has reputation for mental illness, Maxwell declares that this merely is a vicious rumor...despite the fact that he has a great-aunt who lives in a gazebo with a hoot owl, an uncle who beheaded his aunt, and another uncle who believes himself to be a leprechaun.
* TheOtherDarrin: Maxwell's sister Jocelyn was played by actress/model Twiggy Lawson in "Stop the Wedding, I Want To Get Off", but played by Sophie Ward in all subsequent appearances.
* RealitySubtext: Twiggy Lawson playing Jocelyn, Maxwell's sister, in "Stop the Wedding, I Want to Get Off" is a nod to the fact that the whole show was inspired by Fran Drescher's experience in taking care of her daughter.
** In "The Butler, the Husband, the Wife and Her Mother", Fran criticizes Maxwell for wearing bright yellow rain boots with his suit, saying "Normally, you're so GQ. Now, you're the Gorton's Fisherman?". Charles Shaughnessy, who plays Maxwell, had shown up to his original audition wearing those same exact boots.
* RealLifeRelative: Joseph Bologna (Renée Taylor's husband) guest starred in two different episode, one as a SmallNameBigEgo actor and the second as a man wooing Sylvia.
** Chester the Pomeranian was Fran Drescher's real-life dog, which is why he was always so excited around her.
** Fran Drescher's real life parents Morty and Sylvia appeared on the show in several roles, later on as Uncle Stanley and Aunt Rose.
** Lester, Jocelyn's chauffeur in "Stop the Wedding, I Want to Get Off" was played by Twiggy Lawson's real-life husband Leigh Lawson.
* WhatCouldHaveBeen: Originally, there were just two Sheffield children: Brighton and Gracie. The executives suggested that a shy teenaged daughter would serve as an amusing contrast with Fran, which eventually became Maggie.
* YouLookFamiliar: Steve Lawrence, who played Fran's (mostly) unseen father Morty, had appeared as himself with wife Eydie Gorme earlier in the show's run.
** A couple of the extras who play nameless one-shot minor characters like a doctor reappear later as a security guard or priest.
** Not just extras, several celebrities had multiple appearances, once in character and once as themselves. Like Steve Lawrence, it happened with Coolio, Whoopi Goldberg and Rosie O'Donnell as well.
** The girl who played Fran's GenerationXerox cousin Tiffany in a first-season episode played a completely unrelated high school girl named Francine in a fourth-season episode, with both characters being written as "Just like Fran only Brighton's age."