* CelebrityVoiceActor: Lily Tomlin was the voice of Ms. Frizzle, Malcolm-Jamal Warner voiced "the producer," and the ThemeTune was sung by Little Richard. And then there's all the celebrities who voiced "guest" characters (CarolChanning, DollyParton, [[UsefulNotes/AmericanFootball Dan Marino]], etc).
* CrossDressingVoices: [[AvertedTrope Averted]]; all four of the boys are voiced by real boys, and all of their voices break over the course of the series.
* HeyItsThatVoice: Wanda's voice actor, Lisa Yamanaka, is best recognized as Sherry Birkin from VideoGame/ResidentEvil2. Arnold's voice actor was {{Nickelodeon}} star Danny Tamborelli (Little Pete on ''The Adventures of Pete and Pete'' and a cast member on ''AllThat'' during its GoldenAge). That's [[Film/NineToFive Lily Tomlin]] as Ms. Frizzle.
** Also, Eartha Kitt makes an appearance as Keesha's grandmother, and Creator/DomDeLuise as a baker in one of the early episodes. As well as DollyParton.
** In a digital book from 2011, Creator/VeronicaTaylor plays Miss Frizzle.
** Creator/SatomiKoorogi ([[WesternAnimation/{{Thundercats 2011}} Snarf]], [[{{Anime/Pokemon}} Togepi]]) is the Japanese voice of Arnold.
** In Mexico, Ralphie is [[WesternAnimation/DrawnTogether Princess Clara]].
** In Spain, Arnold is WesternAnimation/SpongebobSquarepants, while Wanda is [[TheFairlyOddparents another Wanda]].
** France is interesting. Arnold is [[WesternAnimation/SouthPark Cartman]]; Ms. Frizzle is [[SpongebobSquarepants Sandy Cheeks]]. Ralphie was [[DragonBall Kid Goku]].
** Phoebe's old teacher, Mr. Seedplot, is [[Disney/BeautyAndTheBeast The Beast]] and [[VideoGame/KingsQuestVIHeirTodayGoneTomorrow Prince Alexander]].
* RecursiveAdaptation: There were books based on the book-based TV series. Don't remember that? It's all right; they were pretty awful.
* ScienceMarchesOn: A science show can't stay accurate forever.
** Pluto is still a planet in "Gets Lost in Space".
*** Pluto is also missing Nix, Hydra, Styx, and Kerberos.
** In "The Busasaurus," Ms. Frizzle says that ''Tyrannosaurus Rex'' was the biggest meat-eater of all time. Too bad the discovery of the slightly larger ''Giganotosaurus'' was published in the same year the episode aired. In the same episode, ''Troodon'' is portrayed [[RaptorAttack with scales rather than feathers]].
** Weirdly, "Gets Eaten" has Ms. Frizzle state that all food chains begin with plants, which had been a discredited fact since the discovery of hydrothermal vents in 1977, seventeen years before the episode aired. Even weirder, this error is pointed out in the phone segment, so it's not carelessness. The fictional producer's justification for excluding hydrothermal vents creatures is "Yeah, but they're weird."
*** A slightly better explanation for why they didn't include that in the show was that the ''majority'' of food chains begin with plants... and it's better to introduce children with a solid foundation of patterns before going into depth about all the exceptions.
** The Tongue Map appears.
* TalkingToHimself: The European Spanish dub has Carlos and Ralphie with the same actor.
* TechnologyMarchesOn: As with most things of this nature, the computer episode went out of date the moment it aired. The fact that the computer has a "gajillion gigabyte hard drive" (something we don't even have yet) AND still has a floppy disk.
** Part of the reason we don't have "Gajillion" gigabyte hard drives might be because... well... "Gajillion," is not a number. We do have computers and networks capable of working on Yottabyte levels (10^24 bytes).
** In "Holiday Special," the whole plot revolves around an item being lost while the kids are sorting the school's recycling. As recently as 2007, many modern recycling plants no longer require manually-sorted inputs ("single stream recycling," a.k.a. one big bin for it all).
----