* HeyItsThatGuy: Isaiah Mustafa, currently known as the star of ''Advertising/TheManYourManCouldSmellLike'', appears as an injured football player. A funny ActorAllusion, as he is a former NFL player.
** Creator/KimCoates, best known as [[Series/SonsOfAnarchy Tig Trager]], in an uncredited role as public relations director Charles Whitman.
** Gandu Three Echo, an embittered long-time resident in the facility, is also known as [[TheSuiteLifeOfZackAndCody Arwin]].
** [[Series/StarTrekVoyager Neelix]] is Jones, one of the residents in the facility.
** You may recognize Starkweather as [[TheGreenMile John Coffey]], [[TheWholeNineYards Frankie Figgs]], or even [[Film/{{Daredevil}} the Kingpin]].
** We didn't know [[Series/{{Community}} Shirley]] worked for an [[EvilInc evil corporation]].
** What's [[Film/{{GoldenEye}} Alec Trevelyan]] doing looking after clones?
*** Especially a clone of [[{{Star Wars}} Obi-wan Kenobi]] and [[Film/TheAvengers The Black Widow]]?
* PlayingAgainstType: A meta-example for Creator/MichaelBay. Compared to his other films this one is relatively light on the action, has some decent atmosphere, and the plot is better developed, if recycled from ''Clonus''. All in all it's not the usual popcorn fare he's most famous for making.