** Creator/NealMcDonough reprises the role of Bruce Banner from the [[WesternAnimation/TheIncredibleHulk 90s Hulk animated series]].
** Creator/FredTatasciore is the Hulk for the first time.
** Creator/RonPerlman, who also has some Hulk experience (having voiced both Banner and the Hulk in the '90s ''WesternAnimation/FantasticFour'' and ''WesternAnimation/IronMan'' cartoons) voices Emil Blonsky/Abomination.
** Creator/RichardMoll (also having Hulk experience, as he voiced Abomination in most of his appearances on the 90s Hulk cartoon) voices the Devil Hulk.
** Michael Donovan also reprises his role from Season 2 of the 90s ''Hulk'' cartoon as the Gray Hulk/Joe Fixit.
** Daniel Riordan ([[Anime/TransformersRobotsInDisguise Megatron]]) is Doc Samson.
** Creator/VanessaMarshall is Mercy.
** Creator/KariWahlgren is Nadia Blonsky.
* PlayingAgainstType: Dave Thomas, Doug [=MacKenzie=] himself, playing General Ross? Amazingly, he does a great job.