* BilingualBonus: The "Guatemalan love song" that Jane Lynch sings had Spanish-speaking audiences laughing. It's not a love song.
* DawsonCasting; 19 year old Creator/KatDennings as 16 year old Marla.
** Inverted with 23 year old Creator/SethRogen as Cal who is implied to be much older.
* DyeingForYourArt: The chest-waxing scene? Yeah, one hundred percent real. ''Ouch.'' For the obvious reason, this was a one-take scene. In fact, at one point they almost ripped off Creator/SteveCarell's ''nipple'', because the actress playing the waxer didn't know she was supposed to apply Vaseline to the nipple and was about to rip off the strip when Creator/JuddApatow realized what was happening and yelled cut. You can also see his blood starting to bubble out, as noted in the commentary.
* EnforcedMethodActing: See above.
* RealLifeRelative: Creator/SteveCarell's wife Nancy Walls plays the teen clinic sex counsellor. Creator/LeslieMann, who plays Nicky, is married to Creator/Judd Apatow.
* StarMakingRole: For Creator/SteveCarell.
* ThrowItIn: All of Andy's exclamations during the waxing scene were improvised by Creator/SteveCarell out of the real pain he was going through. Apatow kept separate lists for profane and non-profane ones, so they could mix and match as they pleased.