!! In the TV series:
** Lisa Whelchel seems to have been given opportunities to display her talents in everything from singing to ventriloquism.
** Pippa sings. The actress later had a career as a country singer.
** In a weird sideways manner. The character "Natalie" was based on Mindy Cohn, who at the time was not an actress but a student at a school the producers visited for ideas and inspiration. She was invited to audition, and ended up cast essentially as herself.
** Creator/GeorgeClooney as George Burnett during the 1985 and part of 1986 seasons.
** Molly Ringwald, during her one season stint (the first one; 1979-1980) played Molly Parker.
** Not to mention Geri Jewell as Cousin Geri.
* DisabledCharacterDisabledActor: Geri Jewell, who played Geri, actually has cerebral palsy.
* DyeingForYourArt: Lisa Whelchel's hair was dyed blond for the role of Blair (during her [[Series/TheMickeyMouseClub New Mickey Mouse Club]] run, her hair was a dark brunette). [[LampshadeHanging Lampshaded]] periodically to imply the character's hair is not naturally blond either.
* IAmNotSpock: Nancy [=McKeon=] didn't come back for the reunion, in part because of her commitment to The Division, and in part because she did't want to be TypeCast as Jo anymore.
* TheOtherDarrin: Blair Warner's mom is played by a different actor in Season 3 than was used in Season 1 and no explanation was given.
** Natalie's boyfriend Snake, a.k.a. [[spoiler: Norbert]]
* UnintentionalPeriodPiece: Became one for the 1980s, just compare the [[http://www.youtube.com/watch?v=k_GxXRbSFDg season 2 opening ]] [[http://www.youtube.com/watch?v=iAX7WGCvP7c to the season 7 one]].
* WhatCouldHaveBeen: Despite the number of main characters being thinned between Seasons 1 and 2, production expressed interest in retaining Molly Ringwald as a regular. However, she left to pursue a movie career.
** In one making-of special, the girls mentioned how, in the episode "The First Time," the writers initially had the idea of Blair losing her virginity. Lisa Whelchel objected on religious grounds, and in fact doesn't appear in the episode at all, so the story was given to Natalie instead.
* WrittenInInfirmity: Nancy [=McKeon=] had broken her foot shooting the MadeForTVMovie ''Strange Voices'' shortly before shooting for the final season began; thus resulting in her foot being in a cast for a few early episodes that season.