* ActorExistenceFailure: Narrowly averted as the show had ended right before Eartha Kitt's death.
* HeyItsThatVoice:
** Kuzco is [[Series/JustShootMe Finch]] and [[Series/RulesOfEngagement Russell]]
** Pacha is [[Series/{{Roseanne}} Dan]] and [[WesternAnimation/{{Futurama}} Robot Santa]].
** Yzma is ComicBook/{{Catwoman}}.
** Kronk is [[Series/{{Seinfeld}} Puddy]], [[Series/RulesOfEngagement Jeff]], [[WesternAnimation/FamilyGuy Joe Swanson]] and [[Series/TheTick The Tick.]]
** Chicha, Pacha frustrated wife, is [[Series/JustShootMe Nina Van Horn.]]
** [[TheSuiteLifeOfZackAndCody Zack and Cody]] as Yzma's nephews in one episode.
** [[HannahMontana Miley Cyrus]] as Yatta, one of the waitress at Mudka's.
** Mr. Moleguaco is [[RevengeOfTheNerds Booger]].
** The Japanese dubbed version keeps most of the dubbing voice cast from the original movie, with the sole exception of Kuzco, for obvious reasons:
*** In the TV series, Kuzco [[ShowtaroMorikubo is]] [[{{Naruto}} Shikamaru Nara]] and [[SorcererStabberOrphen Orphen.]]
*** Malina [[YuuAsakawa is]] [[FateStayNight Rider]], [[{{Vandread}} Jura Basil Elden]] and [[{{Vocaloid}} Megurine Luka.]]
* MissingEpisode: For no apparent reason, episodes 43 ("Father O'Mine" and "Everybody Loves Kuzco") and 49 ("Faking the Grade" and "Eco Kuzco") are never shown in the DisneyChannel's rerun rotation. The Kuzcoween, Cornivale, and Giftmas episodes also fall under this, but it's because they're holiday episodes.
* TheOtherDarrin: Fred Tatasciore replaces John Goodman as Pacha for the first season.