* ActorExistenceFailure: Very narrowly averted--the show ended literally just over a month before Eartha Kitt passed away from colon cancer.
* MissingEpisode: For no apparent reason, episodes 43 ("Father O'Mine" and "Everybody Loves Kuzco") and 49 ("Faking the Grade" and "Eco Kuzco") are never shown in the Creator/DisneyChannel's rerun rotation. The Kuzcoween, Cornivale, and Giftmas episodes also fall under this, but it's because they're holiday episodes.
** J.P. Mannix replaces David Spade for the role of Kuzco.
** Fred Tatasciore replaces John Goodman as Pacha. This was only for the first season, [[TheOriginalDarrin as Goodman was able to reprise his role in the second season]].
** Pacha and Chicha's kids get new actors due to the previous ones hitting puberty.
** In the Japanese dub, Creator/ShowtaroMorikubo replaces Tatsuya Fujiwara as Kuzco [[CelebrityVoiceActor for obvious reasons]].
* RealLifeRelative: At the time in the Japanese dub, Creator/ShowtaroMorikubo and Creator/YuuAsakawa (Kuzco and Malina's respective voice actors), were married--however, they're now divorced.
* RoleReprisal: Bob Bergen, Eartha Kitt, Wendie Malick, and Patrick Warburton returned to voicing Bucky the squirrel, Yzma, Chicha, and Kronk. John Goodman returned to voicing Pacha in season 2.