* ActorAllusion: As Warren, Jack Burns would occasionally use his stand up trademark of making a statement to another character then saying "huh?" "huh?" "huh?" until the other character shouts an agreement with him to get him to shut up.
* TheCastShowoff: Andy's singing was showcased in several episodes, as was Jim Nabors'.
* TheDanza: Andy Griffith as Andy Taylor and Elinor Donahue as Ellie Walker
* NamesTheSame: In the episode ''The Bookie Barber'', there is a resident of Mayberry named Creator/EmmaWatson
** Ben Weaver, the department store owner, was played by three different actors over the course of the show.
** Four different actors played Wally, the owner of the filling station.
** Floyd was played by a much older actor in his first appearance.
* ThePeteBest: [=McNear=] took over the role of Floyd after Baldwin's one-time appearance as the character.
** Griffith is a native Tarheel. Mayberry is a pastiche of Mount Airy, where he grew up. Nearby to Mount Airy is Pilot Mountain, renamed to Mount Pilot for the show.
** Being on the show so endeared the state to Frances Bavier that she moved there (specifically to Siler City) later in life.
** Howard [=McNear=] (Floyd TheBarber) had a severe stroke during the run, and upon returning could not walk or stand on his own. He thereafter was always shown sitting or leaning against an object, and would "walk" across the room off camera. When worsening health required him to leave permanently, Floyd retired and the barbershop became Emmett's Fix-It Shop.
* RealLifeRelative: Rance Howard, Ron Howard's real life father, made four separate guest appearances and wrote an episode. And Ron's younger brother Clint made a few early appearances as a young boy named Leon who would often offer people his sandwich.
** At least two different episodes has Barney desperately wanting the big solo in choir - in one such episode, he loses to Gomer, whose singing voice is much more suitable for the solo; in the other, he's over confident that he's got the solo while the rest of the choir try to find a way to get rid of him without hurting his feelings.
** Several early episodes followed the following format: state police and/or feds come to Mayberry to deal with a crime or seek out a dangerous criminal and are frustrated with Andy's country bumpkin nature, eventually ordering him off the case, only to be humbled when he ends up solving the case for them.
* WhatCouldHaveBeen: Originally, Andy was supposed to be the comedic lead with Knotts as his straight man (similar to their roles in ''No Time For Sergeants'', but they quickly discovered it was funnier the other way around: "By the second episode, I knew that Don should be funny, and I should play straight."
** Andy Griffith wanted black actors to have prominent roles in the series, but he was barred from this because of the fact that, being the 1960s, many southern stations would have refused to air the show. This resulted in only a very occasional black extra showing up as a background character in very few episodes, with more prominent characters appearing in the spinoff only, and Mayberry didn't get any solid black characters until the RFD sequel/retool series many years later.
* WriteWhatYouKnow: Mayberry is based very heavily on Griffith's home town of Mount Airy, NC (and Mount Airy is ''quite'' [[SweetHomeAlabama proud of it]]).
* YouLookFamiliar: Several, but the award goes to Allan Melvin appearing as 8 different characters, many of them central to the episode they appeared in.
** Despite already playing the role of Ernest T. Bass, Howard Morris was, for some reason, randomly brought into one episode, in a guest spot as a neurotic TV repairman.
** Perhaps justified in that Howard Morris directed that episode, as well as several others during that particular season.
** In the Backdoor Pilot of the series that aired as an episode of ''The Danny Thomas Show'', Frances Bavier played a woman named Henrietta Perkins rather than Aunt Bea Taylor.