* KeepCirculatingTheTapes: Activision's Spider-Man games were delisted in 2014, this included. While you can find PS2, PSP and DS versions at fair prices, have fun hunting down versions for Xbox 360 and PS3, let alone copies that are even affordable at all. The Wii version is also cheaper, but it is an inferior port of the base console versions.
* RoleReprise:
** Like everything else, there's Creator/SteveBlum as Wolverine.
** Creator/TriciaHelfer reprised her role from ''WesternAnimation/TheSpectacularSpiderMan'' as Black Cat.
* WhatCouldHaveBeen:
** The credits of the Platform/PlayStation3, Platform/Xbox360 and PC versions of the game are accompanied with ConceptArt, one of these pieces is the concept of a Symbiote Moon Knight, who is never infected in the game.
** [[http://www.comicbookmovie.com/fansites/TastyBurgerReviews/news/?a=73588 There were plans to make a sequel]] featuring ComicBook/{{Carnage}} and Mysterio, but it was cancelled when the studio behind the original game was shut down. The design for Mysterio, however, would live on in ''VideoGame/SpiderManShatteredDimensions''.
** An interesting variation but one plan for a sequel was to make it a WhatIf take with Venom being the hero of New York and Spidey, heavily taken over by the Carnage symbiote, would be the villain who causes an almost WORSE variation of what Venom did in this game, essentially quarantining it from the rest of the world. Venom would be able to form different weapons and eat certain enemies. If that kinda sounds familiar? It should. It's now known as ''VideoGame/{{Prototype}}''.
* WorkingTitle: The game is referred to as ''Spider-Man: Red vs. Black'' in concept art, in reference to the game's symbiote mechanic.
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