* CelebrityVoiceActor: At the time of the game's release, Creator/{{Activision}} made a big deal about the casting of Creator/ValKilmer as Walker Sloan, Creator/KateeSackhoff as ComicBook/BlackCat, and Creator/LauraVandervoort as ComicBook/MaryJaneWatson.
* DuelingGames: ''VideoGame/BatmanArkhamCity'' launched around the same time.
* TheOtherDarrin:
** An interesting variant -- Creator/{{Josh|Keaton}} [[WesternAnimation/TheSpectacularSpiderMan Keaton]] and Creator/{{Christopher Dan|iel Barnes}}[[WesternAnimation/SpiderManTheAnimatedSeries iel Barnes]] return from ''[[VideoGame/SpiderManShatteredDimensions Shattered Dimensions]]'' as the voices of the Amazing Spider-Man & ComicBook/SpiderMan2099 respectively... replacing Creator/{{Neil Pat|rickHarris}}[[WesternAnimation/SpiderManTheNewAnimatedSeries rick Harris]] and [[WesternAnimation/SpiderManAndHisAmazingFriends Dan Gilvezan]], who voiced the characters in ''Shattered Dimensions'', whilst Josh and Chris voiced the Spider-Men of the [[ComicBook/UltimateSpiderMan Ultimate]] and [[ComicBook/SpiderManNoir Noir]] universes. Josh also provided the voice of the Amazing Spider-Man in the DS port of ''Shattered Dimensions''.
** In the French dub of ''Shattered Dimensions'', Spider-Man 2099 was voiced by Benjamin Pascal. Here, he's instead voiced by Creator/AdrienAntoine.
* RecycledScript: This is not the first ComicBook/SpiderMan game to [[spoiler: [[VideoGame/SpiderMan2000 have a Symbiote (or, in this case, something similar) merge]] with ComicBook/DoctorOctopus]].
* RefittedForSequel: [[spoiler:The CEO of Alchemax being Peter Parker was Peter David's original plan in the 2099 comics, and was integrated for this game.]]
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