* ActorAllusion: Ham III is basically [[WellDoneSonGuy Rod]] (from ''Film/HotRod'') as a chimp - both are played by [[Music/TheLonelyIsland Andy Samberg]].
* CreatorKiller: The sequel's critical and box office failure killed its animation studio.
** In the first film, Ham was voiced by Andy Samberg. In the second one, TomKenny took over.
** Both Kilowatt and Zartog have their well-known actors (Kristin Chenoweth and Jeff Daniels) replaced with Creator/LauraBailey and Creator/JohnDiMaggio (the former sounding [[MostAnnoyingSound stunningly annoying]] and the latter sounding bored like no tomorrow. Which is a shame since they're both talented actors otherwise.