* BTeamSequel: Creator/JamesWhale had no desire to make any more horror films and thus didn't return to direct.
* TheCharacterDiedWithHim: Colin Clive died before production began, and Baron Henry Frankenstein is all but stated to have died between the events of this film and the previous film, ''Film/BrideOfFrankenstein''.
* UncreditedRole: Surprisingly for a film as dependent on make-up effects as this one, make-up supervisor Jack Pierce receives no on-screen credit for his work.
* WhatCouldHaveBeen:
** Creator/PeterLorre was originally cast as Baron Wolf von Frankenstein, but he had to leave the production when he became ill. Creator/ClaudeRains was also considered.
** There were plans to shoot the film in Technicolor, but Jack Pierce was reportedly unable to make the makeup for the monster look right in color.
* WritingByTheSeatOfYourPants: Due to the lack of a prepared script, much of the picture was written just moments before the actors were to shoot their scenes. This was how director Rowland V. Lee was able to keep Creator/BelaLugosi working throughout filming, and built up the role of Ygor, which never appeared in the original Wyllis Cooper screenplay.
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