* ActingForTwo:
** Creator/SatsukiYukino voices Yuna and the younger Koga.
** Creator/EijiTakemoto voices Mirfak and Titan.
** Creator/{{Yukana}} voices both Paradox and [[spoiler:her twin sister Integra. She spends a good portion of episodes 75 and 84 switching between the two characters.]]
** Creator/ShigeruNakahara voices Kiki and Sho.
* TheOriginalDarrin:
** Creator/MasakazuMorita, who has been voicing Seiya since the ''Hades Saga: Inferno'' and ''Elysium'' [=OVAs=], was replaced by Creator/ToruFuruya, who previously voiced Seiya in the ''Heaven Chapter – Overture'' film eight years earlier.
** Creator/MamiKoyama also returns to voice Shaina for the first time since the ''Heaven Chapter – Overture'' film, after being replaced by Creator/YukaKomatsu for the ''Hades Saga: Inferno'' and ''Elysium'' [=OVAs=].
* TheOtherDarrin:
** A significant amount of characters are not reprised by the actors who voiced them in their appearances in the previous ''Saint Seiya'' series, [=OVAs=] and films. For example:
*** Shoko Nakagawa is darrining Creator/KeikoHan and Creator/FumikoOrikasa as Saori/Athena.
*** The late Creator/KiyoyukiYanada replaced Yuji Mikimoto and Kohei Fukuhara as Geki.
*** Creator/TakeshiKusao voices Jabu instead of Kosuke Meguro and Creator/HideoIshikawa.
*** Creator/TetsuInada voices Ban instead of Creator/HirohikoKakegawa and Naoki Imamura.
*** Creator/HiroshiKamiya is replacing Creator/RyoHorikawa and Yuta Kazuya as [[spoiler: Andromeda Shun]].
*** Creator/ShigeruNakahara darrin'd Creator/HirokoEmori and Umeka Shoji as Kiki ([[SheIsAllGrownUp well he's an adult now so it's understandable]])
*** Creator/MamoruMiyano replaced Creator/HiroakiMiura and Creator/KoichiHashimoto as [[spoiler:Cygnus Hyoga]].
*** Creator/TomokazuSugita replaced Creator/HideyukiHori and Creator/KatsuyukiKonishi as [[spoiler:Phoenix Ikki]].
*** Creator/KenNarita replaces the late Creator/HirotakaSuzuoki and not-late Creator/TakahiroSakurai as [[spoiler: Dragon Shiryu]].
*** Creator/KonamiYoshida becomes the fourth voice actress to play Shunrei, after being previously voiced by Creator/YumikoShibata for the TV series, Creator/ErikoSato for the ''Hades Saga: Sanctuary'' OVA and Ai Bando for the ''Hades Saga: Elysion'' OVA.
** In the Latin American Spanish dub of the second season, Juan Alfonso Carralero decided not to reprise his role as Taurus Harbingir, so Carralero was replaced by Creator/AlfonsoObregonInclan.
* TheOtherMarty: In the Latin American Spanish dub, Creator/YamilAtala originally voiced Pegasus Seiya during the first episode's production, but he was replaced by his classic VA Creator/JesusBarrero after the latter settled his budgetary disagreements. Atala would later be cast as Libra Genbu and Marine Ushio.
* PlayingAgainstType: Creator/HikaruMidorikawa (Koga), as he tends to play cool, collected characters.
* RecastAsARegular: Creator/SatsukiYukino voiced Seika in the ''Hades Saga: Elysion'' OVA before playing Yuna in ''Omega''.
* RecycledScript: The whole first season was ''heavily'' based on the Sanctuary arc of the original series, to the point of being called just a rehash. Bronze Saint tournament, journey overlapping with battle against the Silver Saints, and then ''another'' "climb the Twelve Temples" arc. Many new characters are [[{{Expy}} very similar]] to old ones, too.
* RealLifeRelative: In the Latin American Spanish dub, real-life brothers Luis Fernando and Creator/AlejandroOrozco play Max Brilliant Methone and Soul Killer Cyllene, respectively.
* RoleReprise:
** In the Japanese release:
*** Creator/ShigeruNakahara and Creator/HochuOtsuka respectively voiced Sho and Ushio in the ''Saint Seiya'' TV series and reprised those roles in ''Omega'' 25 years later.
*** Creator/ToruFuruya and Creator/MamiKoyama respectively return to voice Seiya and Shaina eight years after last voicing them in the ''Heaven Chapter – Overture'' film.
*** Creator/YukitoshiHori reprises his role as Tatsumi 10 years after last voicing him in the ''Hades Saga: Sanctuary'' OVA.
*** Creator/MasayaOnosaka returns to voice Ichi 6 years after his last appearance in the ''Hades Saga: Elysion'' OVA.
** Many of the Latin American Spanish dubbers from the original series got to keep their roles as well. Some of the few exceptions include Jesse Conde voicing Dohko after the passing of his original VA Eduardo Borja, but even that's a reprise from the Hades Saga's T.V. Dub.
* RomanceOnTheSet: Gerardo Alonso and Jahel Morga, the Latin American Spanish voice actors for Wolf Haruto and Aquila Yuna, married in October 2013, two months after dubbing the first season of ''Omega''.
* WhatCouldHaveBeen:
** In the Latin American Spanish dub, Creator/YamilAtala originally [[TheOtherDarrin replaced]] the late Creator/JesusBarrero as Pegasus Seiya due to the latter's disagreement with the budget and Atala even recorded some of his lines as Seiya for the first episode. However, this ended up being a case of TheOtherMarty when Barrero amicably settled his budget dispute and reprised his role, re-dubbing Atala's dialogue from the first episodes. As a bonus, Atala stayed in the cast and went on to voice both Libra Genbu and Marine Ushio.
** Also from the Latin American Spanish dub: Mireya Mendoza (Relena from ''Anime/GundamWing'', Shizune from ''Manga/{{Naruto}}'', Penny from ''Series/TheBigBangTheory'', etc) was at first contacted to play Saori/Athena, a role she also played in the [=TV=] dub of the Hades [=OVA=]s, but she told the casting people to contact Saori's classic VA Creator/MariaFernandaMorales and offer ''her'' the role, which Mendoza would only take if Morales was unavaliable. They did, and Morales accepted to voice Saori again.
* YouSoundFamiliar:
** Creator/KatsuyukiKonishi, who took over for Creator/HideyukiHori as Phoenix Ikki starting with the ''Hades Saga: Inferno'' [=OVAs=], voices Soma in ''Omega''.
** Jabu is voiced by Creator/TakeshiKusao, who replaced the late Creator/KojiTotani as Shura.
** Creator/EijiTakemoto previously voiced Valentine in the ''Hades Saga'' [=OVAs=] before voicing Mirfak and Titan here.
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