* TheOtherDarrin
** Paul Mercier (who voiced Leon in ''VideoGame/ResidentEvil4'', ''[[VideoGame/ResidentEvilTheDarksideChronicles The Darkside Chronicles]]'', and ''[[Anime/ResidentEvilDegeneration Degeneration]]'') was replaced with Matthew Mercer (who also voices Leon in ''VideoGame/ResidentEvil6'').
** Sally Cahill (who voiced Ada in ''VideoGame/ResidentEvil 2'', ''Resident Evil 4'' and ''The Darkside Chronicles'') was replaced by Courtenay Taylor (who also voiced Ada in ''Resident Evil 6'').
* PlayingAgainstType: Creator/WendeeLee, a villain, no way!
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