* ActorAllusion: This isn't the first time LauraBailey plays a character who is [[spoiler:forced to kill a loved one, and a sibling at that]]. In a ''Resident Evil'' production as well.
* AscendedFanboy: Creator/MatthewMercer, Leon's current VA, also known for ''ThereWillBeBrawl'', have been a long running fan of the series, with Leon being his favorite character.
* FanNickname
** Blue Ada [[spoiler: for Carla Radames]]
** Bionic Nemesis for the Ustanak, since it's essentially Nemesis with Spencer's '''[[MarvelVSCapcom3 BIONIC AAARRRRRMMM!!!]]''' from ''VideoGame/BionicCommando''.
** Plot Dump: The Campaign for Ada's campaign.[[labelnote:Explanation]]Resulting from the majority of the game's plot details and backstories of the villains and other important information that is found through the Serpent Emblems on Ada's campaign.[[/labelnote]]
** The healing tablets in the game tend to be referred to by players as "Tic-Tacs," after the candy.
** Ada Wrong and Fake-Ada, for the Ada [[spoiler:clone]] who's wreaking havoc. Alternatively, Ada Wong and Ada Wrong.
*** Alternatively, Red Ada and Blue Ada.
** Resident Evil: Modern Warfare, for the added focus on shooter mechanics.
*** Alternatively, Resident Gears of Duty.
* GeniusBonus: During Chapter 3 of Chris' campaign, while tracking the Iluzja through the Poisawan district, one part of the area resembles an extremely unhygenic dentist's office, complete with a filthy glass case full of dentures. In real life, the Kowloon Walled City, which this part of the game was based on, was infamous for it's large number of unlicensed dentists, and a case full of dentures almost identical to the one seen in the game was featured in an old German documentary about the Walled City.
* HeyItsThatVoice: Creator/LauraBailey voices Helena Harper, Creator/TroyBaker voices Jake Muller (you can think about Jake as an adult [[VideoGame/{{Persona 4}} Kanji Tatsumi]]), Creator/EdenRiegel plays Sherry Birkin (reprising her role from Operation Raccoon City), and Creator/YuriLowenthal voices Finn Macauley. Ada's [[TheOtherDarrin new voice actress]] is Courtenay Taylor, better known as [[VideoGame/MassEffect2 Jack's]] [[VideoGame/MassEffect3 voice.]]
** In the upcoming DLC Japanese voice pack, Creator/ToshiyukiMorikawa reprises his role as Leon from Japanese dub of ''[[ResidentEvilOperationRaccoonCity Operation Raccoon City]]'' and ''[[ResidentEvilDamnation Damnation]]'', Creator/HirokiTochi reprises his role as Chris since ''MarvelVsCapcom3'', Creator/DaisukeNamikawa as Jake, Creator/MaayaSakamoto as Sherry, and Creator/JunkoMinagawa reprises her role as Ada from ''ORC'' too.
** HeyItsThatGuy: Leon's mocap actor is none other than Jason Faunt, better known as Wes from ''Series/PowerRangersTimeForce''.
*** Which becomes HilariousInHindsight when you remember that ''DevilMayCry'' started out as an early concept for ''VideoGame/ResidentEvil4'', and features Creator/ReubenLangdon as Dante from ''[=DMC3=]'' onwards, and Langdon served as Faunt's stunt double on ''Time Force''. Not to mention that Creator/ReubenLangdon is Chris' mocap actor in both this game and VideoGame/ResidentEvil5. And to go even further, guess who also is part of mocap team? Daniel Southworth, who played Eric/Quantum Ranger from ''Series/PowerRangersTimeForce'' alongside Faunt, is a backup stunt double for Jake.
** RelationshipVoiceActor: Helena is Creator/LauraBailey and Leon is Creator/MatthewMercer. [[VideoGame/FireEmblemAwakening Chrom and "Marth"]]/[[spoiler: Lucina]] fighting together again! Which can be squicky if you ship them together for [[spoiler: ParentalIncest]] reasons.
*** In upcoming Japanese voice pack DLC, Sherry voiced by Creator/MaayaSakamoto and Jake voiced by Creator/DaisukeNamikawa. Fans who ever played ''Persona4Arena'' will realized that both VA voicing [[{{Persona3}} another]] [[VideoGame/{{Persona 4}} character]] with Wild Card potential.
* RecycledScript[=/=]PropRecycling: Most of Leon's campaign uses settings and plot elements very familiar to past games, among other things he ends up [[VideoGame/ResidentEvil2 in a city filled with zombies]] (to the point he even meets a cop on his first day and goes to a gunshop to stay safe), [[VideoGame/ResidentEvil ends up in a mansion with its own dark secrets]], [[VideoGame/ResidentEvil4 said mansion featuring underground catacombs]].
** The same can be said the other campaigns, to a degree. The game recycles the angry, brooding, vengeance-driven Chris from VideoGame/ResidentEvil5 during the majority of his chapters. Jake and Sherry's campaign can be seen as a retake on VideoGame/ResidentEvil3 (Ustanak being the Nemesis counterpart). Ada's campaign is much like her VideoGame/ResidentEvil4 campaign, tailing the rest of the cast and filling in details as she goes along.
* UrbanLegendOfZelda:
** Carla Radamedz was largely believed to be a fake character not in the game before the game's release, to the point that "I believe in Carla Radames" became somewhat of a MemeticMutation.
** Rumors circulated of an UpdatedRerelease known as ''Resident Evil 6: Final Hope'' which would bring the game to Wii U as well as include an additional campaign for Claire Redfield.