* FakeNationality: Josh Stone, who speaks with an African accent, is voiced by TJ Storm, an American.
* FanNickname: Chris is referred to as "Chris Roidfield", thanks to his bulky appearance.
* LetsPlay: One particularly good co-op Let's Play was done by LetsPlay/ProtonJon and LetsPlay/SuperJeenius [[https://youtube.com/playlist?list=PLyiQDjAWHJJa4YJ1aBaqKfLg_fFRL6NHJ here.]]
* NamesTheSame: Music-wise, Jill's boss theme, "Sad But True", is also the name of songs by Music/{{Metallica}} and Music/{{Orbital}}.
* WhatCouldHaveBeen: Not to the extent of ''4'', but nevertheless the game underwent a number of changes before release, many which are detailed in ''The Art of Resident Evil 5'':
** The game was originally designed as a single-player game akin to ''4'', with Chris as the only playable character. Sheva was originally intended to be a recurring character, being the head of a local militia fighting against the outbreak. When the decision was made to make the game support two-player cooperative, Sheva was rewritten as a BSAA operative and Chris's partner.
** Jill was originally to be found [[spoiler:frozen and used by Wesker for research in the TRICELL facility]], but it was decided it wasn't interesting enough.
** Barry Burton was meant to appear multiple times during the game, at one point assisting in a boss fight against no less than ''ten'' El Gigantes. He ended up cut from the storyline completely, though he would be a playable character in ''The Mercenaries Reunion'' in the ''Gold Edition''.
** Excella would have simply been a secretary to Tricell, and her death was portrayed very differently (she would have died in the hands of a Tyrant-like creature, ''literally''), and the Tricell CEO would have been a different, male character. The two characters were ultimately combined in order to create a powerful female villain.
** A placeholder model for a merchant character was found in the files of the game, suggesting that the Merchant from ''4'' was intended to return at some point in development. Also found in the game files was a player model version of Ricardo Irving, suggesting he had been intended to be a playable character for ''The Mercenaries'' mode.
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