* EnforcedMethodActing: Philip Seymour Hoffman was glued to the chair for real, at his own request.
* FakeAmerican: Englishman Creator/RalphFiennes plays the American Francis Dolarhyde.
* HeyItsThatGuy:
** William Peterson's performance in this movie can be seen as an extended audition for his role as Gil Grissom on Series/{{CSI}}.
** Ralph is [[Series/RayDonovan Van Miller]]. [[spoiler:He meets [[BoomHeadshot a similar end]].]]
* TheOtherDarrin: Everyone at some point.
* WhatCouldHaveBeen: According to the Red Dragon commentary, Philip Seymour Hoffman very much wanted to play Dolarhyde.
* Frank Langella recorded a number of lines as the voice of the Great Red Dragon, allowing viewers to hear Dolarhyde's interior monologue/argument, but they were cut.
* Frankie Faison played Barney the orderly in ''SilenceOfTheLambs'', ''Film/RedDragon'', and ''Film/{{Hannibal}}''. Due to scheduling, he did not become available to appear in ''Film/RedDragon'' until the last minute. Screenwriter Ted Tally has commented that, had he known for sure that Faison would be able to take the part, Barney would have had a bigger role.