* EnforcedMethodActing: Philip Seymour Hoffman was glued to the chair for real, at his own request.
* FakeAmerican: Englishman Creator/RalphFiennes plays the American Francis Dolarhyde.
* HeyItsThatGuy:
** William Peterson's performance in this movie can be seen as an extended audition for his role as Gil Grissom on Series/{{CSI}}.
** Ralph is [[Series/RayDonovan Van Miller]]. [[spoiler:He meets [[BoomHeadshot a similar end]].]]
* TheOtherDarrin: Everyone at some point.
* TechnologyMarchesOn: Dolarhyde chooses his victims through their home movies, which are shot on film and are sent to his company for processing. This plot device was outdated by the mid-80s when the camcorder became a reality. The 2002 adaptation updates the story to Dolarhyde's company compositing shorter home movies into VHS tapes (as the timeframe set by ''Silence of the Lambs'' meant the movie had to take place in the mid-80s instead of the late 70s). Of course, that too is wildly outdated. Today Dolarhyde would just stalk victims on Youtube.
* WhatCouldHaveBeen: According to the Red Dragon commentary, Philip Seymour Hoffman very much wanted to play Dolarhyde.
* Frank Langella recorded a number of lines as the voice of the Great Red Dragon, allowing viewers to hear Dolarhyde's interior monologue/argument, but they were cut.
* Frankie Faison played Barney the orderly in ''SilenceOfTheLambs'', ''Film/RedDragon'', and ''Film/{{Hannibal}}''. Due to scheduling, he did not become available to appear in ''Film/RedDragon'' until the last minute. Screenwriter Ted Tally has commented that, had he known for sure that Faison would be able to take the part, Barney would have had a bigger role.