* ActorAllusion: Many, but the most obvious one is when Rango is flying through the air on the highway, he smacks into the windshield of a car driven by [[Literature/FearAndLoathingInLasVegas Raoul Duke and Dr. Gonzo]]. (It doesn't hurt Rango himself wears Duke's Hawaiian shirt.)
** Rango dons a dress at one point in the film; [[Film/EdWood this isn't the first time a Johnny Depp character has worn a dress.]]
** When Rango is in his tank and trying out various different characters, some of them seem to be allusions to other roles of Depp's, including [[Film/PiratesOfTheCaribbean a grizzled sea captain]] and [[DonJuanDeMarco a Latin lover]].
*** Speaking of ''Film/PiratesOfTheCaribbean'', Rango is carried away by woodlice in a brief scene, where he later [[spoiler: finds a boat in the middle of a salt flat]].
**** He also runs like Jack Sparrow, leaning back, arms akimbo.
**** And like Jack in the first ''Film/PiratesOfTheCaribbean'' movie, Rango is also armed with [[OneBulletLeft one bullet]].
**** "That's interesting."
**** "Hola."
** [[spoiler: The Spirit of the West]] is voiced by Timothy Olyphant--a brilliant three-pronged ShoutOut to ''Series/{{Justified}}'', ''{{Series/Deadwood}}'', and ''Film/TheGoodTheBadAndTheUgly'' as his character model is a Creator/ClintEastwood look alike.
** Also, this isn't the first time Bill Nighy has portrayed a [[Film/PiratesOfTheCaribbean feared Grim-Reaper figure]].
* AllStarCast: Creator/JohnnyDeep as Rango, Bill Nighy, Alfred Molina, Creator/AbigailBreslin and Creator/IslaFisher to name a few.
* FakeAmerican: Isla Fisher as Beans.
** And Bill Nighy as Jake.
* HeyItsThatVoice
** JohnnyDepp and Bill Nighy (who respectively played [[Franchise/PiratesOfTheCaribbean Jack Sparrow and Davy Jones]]), are Rango and Rattlesnake Jake.
** The armadillo was Creator/AlfredMolina, better known as [[Film/SpiderMan2 Dr. Octopus]].
** Also Creator/AbigailBreslin AKA Olive in ''LittleMissSunshine'' as Priscilla. Creator/IslaFisher, who played Gloria in ''Film/WeddingCrashers'' as Beans. Ned Beatty, who played Lotso in ''WesternAnimation/ToyStory3'', as the mayor and TimothyOlyphant (better known as Raylan Givens from ''Series/{{Justified}})'') as [[spoiler:The Spirit of the West]].
** [[WesternAnimation/KingOfTheHill Buck Strickland]] and [[OfficeSpace Milton]] are Doc and Merrimack.
** Wounded Bird is Gil Birmingham, an actor who's played another [[Literature/{{Twilight}} crippled Native American]].
** Angélique is voiced by Creator/ClaudiaBlack.
** Vincent Kartheiser belongs to the bank robbing trio.
** Ambrose is [[StarWarsTheCloneWars Palpatine]].
** Considering that this was released shortly after ''WesternAnimation/ToyStory3'', the Mayor and Buford the bartender were Lots-O-Huggin' Bear and Slinky Dog, respectively.
** The Japanese dub doesn't skimp out on notable names either, including...
*** HiroakiHirata as Rango
*** Creator/TesshoGenda as the Mayor
*** Creator/{{Chafurin}} as Merrimack the bank teller
*** Creator/WataruTakagi is Waffles
*** Creator/AtsukoTanaka as Angelique
*** Creator/NaoyaUchida as Elgin the Bobcat
*** Creator/RokuroNaya as Spoons
*** [=George DelHoyo=], the voice that does previews on FOX, is Senor Flan the owl.
* First lines Rango says in the film? [[LeaningOnTheFourthWall That's Johnny Depp warming up.]]
* How many Academy Awards does Clint Eastwood have? Five. How many 'golden guardians' does the Spirit of the West, an {{expy}} of TheManWithNoName, have? Five.
* Rango's name, despite being Durango without the Du, is most likely a refference to Ringo, the main character of APistolForRingo, an SpaghettiWestern staring Giuliano Gemma.
* Appearing as Lotso in ''ToyStory3'' and the Mayor in this film means that Ned Beatty was in two Academy Award-winning animated films in a row. [[spoiler: In both cases, he plays the BigBad.]]
* Album cover artist Roger Deakins was the responsible for the film's unique look.
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