* ActingForTwo: Cloris Leachman plays both Barbara-June "Maw Maw" Thompson and her 104 year old mother Norma June Thompson in "Mother's Day".
* ActorAllusion:
** In the Episode "A Germ of a Story" when watching home movie from Virginia's childhood, Burt says Maw Maw looks like the ''hot'' neighbor from ''Series/TheMaryTylerMooreShow'' -- Cloris Leachman portrayed Phyllis Lindstrom on that show.
** Virginia calls the whipped husband played by Ethan Suplee from the episode "Baby Monitor", "...a skinny version of the dude from ''Film/{{Mallrats}}''." Ethan Suplee ''did'' play that character in the movie.
** Smokey Floyd, played by Jason Lee A.K.A Earl Hickey, calls Barney (Gregg Binkley) "Kenny" by accident. Guess the name of the character Binkley played in ''Series/MyNameIsEarl''.
*** Smokey Floyd returns in "Making The Band" with a list of people he's wronged that he is making amends to, complete with ''My Name is Earl'' theme music, he is joined by the actors who played Randy, Darnell, Joy and Catalina as well as TV's Tim Stack.
** In the ItsAWonderfulPlot Christmas episode, Maw Maw plays the angel. Cloris Leachman once played this role in ''It Happened One Christmas'', a gender-flipped version of ''Film/ItsAWonderfulLife''. There was also a version of the ItsAWonderfulPlot when Leachman was on ''Series/TheFactsOfLife''.
** In "Yo Zappa Do", Brian Doyle-Murray appears as [[Series/YesDear a president of a movie studio]]. Of course, considering who appears next, it could have been the actual Mr. Savitsky. In the same episode, Virginia (Martha Plimpton) points out that child actors never last, that they appear in a [[Film/TheGoonies Steven Spielberg movie]] and then end up "as the mom on a wacky sitcom".
** "Credit Where Credit Is Due" features [[Franchise/BackToTheFuture a DeLorean and Christopher Lloyd.]]
* TheCastShowoff: More of a guest-star showoff, but if Kate Miccuci is in an episode, she'll likely be singing and playing the ukelele.
* FridayNightDeathSlot: The fourth (and final) season moved to Friday.
* PlayingAgainstType: Garret Dillahunt, who is better known for playing sociopaths and other unsavory characters, as the loving yet dumb and harmless Burt Chance.
* RealLifeRelative: In the first season finale we meet Lucy's first victim, played by Bijou Phillips' actual husband, [[Series/That70sShow Danny Masterson]]. In the episode "Anniversary", the cowboy running the dude ranch is veteran character actor Keith Carradine, Martha Plimpton's (Virginia) father.
* SeparatedAtBirthCasting: Teenage Virginia, Kelly Heyer, looks uncannily like Martha Plimpton. The show later recast teenage Burt with Corey Eid, who similarly resembles Garret Dillahunt.