* ActingForTwo: Cloris Leachman plays both Barbara-June "Maw Maw" Thompson and her 104 year old mother Norma June Thompson in "Mother's Day".
* ActorAllusion: In the Episode "A Germ of a Story" when watching home movie from Virginia's childhood, Burt says Maw Maw looks like the neighbor from TheMaryTylerMooreShow - Cloris Leachman's character on that show.
** Virginia calls the whipped husband played by Ethan Suplee from the episode "Baby Monitor", "...a skinny version of the dude from MallRats." Ethan Suplee ''did'' play that character in the movie.
** Smokey Floyd, played by [[MyNameIsEarl Jason Lee A.K.A Earl Hickey]], calls Barney (Gregg Binkley) "Kenny" by accident. Guess the name of the character Binkley played in MyNameIsEarl...
*** Smokey Floyd returns in "Making The Band" with a list of people he's wronged that he is making amends to, complete with ''Series/MyNameIsEarl'' theme music, he is joined by the actors who played Randy, Darnell, Joy and Catalina as well as TV's Tim Stack.
** In the ItsAWonderfulPlot episode, Maw Maw plays the angel. Cloris Leachman once played this role in ''It Happened One Christmas'', a gender-flipped version of ItsAWonderfulLife. There was also a version of the ItsAWonderfulPlot when Leachman was on ''Series/TheFactsOfLife''.
** In "Yo Zappa Do", Brian Doyle-Murray appears as [[Series/YesDear a president of a movie studio]]. Of course considering who appear next, it could have been the actual Mr. Savitsky. In the same episode, Virginia points out that child actors never last. They appear in a [[Film/TheGoonies Steven Spielberg movie]] and then end up "as the mom on a wacky sitcom."
** "Credit Where Credit Is Due" features [[Film/BackToTheFuture a DeLorean and Christopher Lloyd.]]
* FridayNightDeathSlot: The fourth (And final) season moved to Friday.
* PlayingAgainstType: Garret Dillahunt, who is better known for playing sociopaths and other unsavory characters, as the loving yet dumb and harmless Burt Chance.