* ActingForTwo: Cloris Leachman plays both Barbara-June "Maw Maw" Thompson and her 104 year old mother Norma June Thompson in "Mother's Day".
* ActorAllusion:
** In the Episode "A Germ of a Story" when watching home movie from Virginia's childhood, Burt says Maw Maw looks like the neighbor from TheMaryTylerMooreShow - Cloris Leachman's character on that show.
** Virginia calls the whipped husband played by Ethan Suplee from the episode "Baby Monitor", "...a skinny version of the dude from ''Film/{{Mallrats}}''." Ethan Suplee ''did'' play that character in the movie.
** Smokey Floyd, played by [[MyNameIsEarl Jason Lee A.K.A Earl Hickey]], calls Barney (Gregg Binkley) "Kenny" by accident. Guess the name of the character Binkley played in MyNameIsEarl...
*** Smokey Floyd returns in "Making The Band" with a list of people he's wronged that he is making amends to, complete with ''Series/MyNameIsEarl'' theme music, he is joined by the actors who played Randy, Darnell, Joy and Catalina as well as TV's Tim Stack.
** In the ItsAWonderfulPlot episode, Maw Maw plays the angel. Cloris Leachman once played this role in ''It Happened One Christmas'', a gender-flipped version of ItsAWonderfulLife. There was also a version of the ItsAWonderfulPlot when Leachman was on ''Series/TheFactsOfLife''.
** In "Yo Zappa Do", Brian Doyle-Murray appears as [[Series/YesDear a president of a movie studio]]. Of course considering who appear next, it could have been the actual Mr. Savitsky. In the same episode, Virginia points out that child actors never last. They appear in a [[Film/TheGoonies Steven Spielberg movie]] and then end up "as the mom on a wacky sitcom."
** "Credit Where Credit Is Due" features [[Franchise/BackToTheFuture a DeLorean and Christopher Lloyd.]]
* TheCastShowoff: More of a guest-star showoff, but if Kate Miccuci is in an episode, she'll likely be singing and playing the ukelele.
* FridayNightDeathSlot: The fourth (and final) season moved to Friday.
* PlayingAgainstType: Garret Dillahunt, who is better known for playing sociopaths and other unsavory characters, as the loving yet dumb and harmless Burt Chance.
* RealLifeRelative: In the first season finale we see Lucy's first victim, played by Bijou Phillips' actual husband, [[Series/That70sShow Danny Masterson]]. In the episode "Anniversary", the cowboy running the dude ranch is veteran character actor Keith Carradine, Martha Plimpton's (Virginia) father.
* SeparatedAtBirthCasting: Teenage Virginia, Kelly Heyer, looks uncannily like Martha Plimpton. The show later recast teenage Burt with Corey Eid, who similarly resembles Garret Dillahunt.