* CaliforniaDoubling: The movie popularized the use of Canada for portraying USA in film.
* CreatorBacklash:
** Creator/JohnFrankenheimer battled alcoholism throughout the shoot and later [[ItsAllMyFault blamed himself]] for the film's worst elements (including the decision to make the Kahtadin a mutant bear instead of the chimera-monster implied in the script). While it performed decently at the box office, ''Prophecy'' was slaughtered by critics and became a minor Main/CreatorKiller for Frankenheimer, relegating him to [[MoneyDearBoy paycheck films]] and direct to video work through the '80s and '90s.
** On the other hand, Creator/TaliaShire and Creator/ArmandAssante have spoken more positively about ''Prophecy''. Assante [[http://thehollywoodinterview.blogspot.com/2008/02/armand-assante-hollywood-interview.html has said]] that he appreciated [[AwesomeDearBoy the opportunity to work with John Frankenheimer]], whom he considers "one of the great directors," and that he liked the story although he thought the bear effects were cheesy. Shire [[https://www.comingsoon.net/movies/news/1140422-talia-shire-reflects-on-the-cult-film-prophecy-40-years-later comments]] that while her feelings on the film are mixed, she does feel its ecological message was ahead of its time, and is glad that the film has acquired a cult following over the years.
* TheDanza: Creator/RobertFoxworth as Dr. Robert Verne.
* FakeNationality: Plenty of the Native Americans are played by US or Canadian actors.
* FollowTheLeader: A horror story about an unlikely killer creature set in Maine. Hmm... Creator/StephenKing is actually on record as liking this movie, though.
* SimilarlyNamedWorks: With the religious horror film ''Film/TheProphecy''.